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What do systematic reviews say?

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Evidence found and GRADE certainty

119 questions · 125 findings · 20 reviews · Airways

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No studies found 22 · 17.6%GRADE not reported 6 · 4.8%Very low 18 · 14.4%Low 29 · 23.2%Moderate 38 · 30.4%High 12 · 9.6%

Macrolides vs placebo

Hospitalisation (any cause) · adults with bronchiectasis

Macrolides showed no clear difference in hospitalisation: all cause compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Serious adverse events · adults with bronchiectasis

Macrolides showed no clear difference in serious adverse events compared with placebo (low certainty).

1 finding from 1 review

Macrolides vs placebo

Quality of life: 1a. Average endpoint scores on various scales (MSQoL‐54, high = good) ‐ short term · adults with bronchiectasis
1 finding from 1 review

Macrolides vs no intervention

Exacerbations (number of people experiencing ≥ 1 exacerbations) · adults with bronchiectasis

Macrolides showed no clear difference in ≥ 1 exacerbation compared with no intervention (moderate certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Successful treatment of exacerbation: number of participants cured. Outcome assessed on day 42 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes successful treatment of exacerbation: number of participants cured.… compared with oral monotherapy (very low certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Successful treatment of exacerbation: number of participants with P aeruginosa eradication. Outcome assessed on day 21 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes successful treatment of exacerbation: number of participants with P… compared with oral monotherapy (very low certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Serious adverse events. Outcome assessed on day 42 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes serious adverse events. Outcome assessed on day 42 compared with oral monotherapy (very low certainty).

1 finding from 1 review

Oral + inhaled dual therapy vs oral monotherapy

Microbiological response: eradicated. Outcome assessed on day 21 · bronchiectasis

It is very uncertain whether oral + inhaled dual therapy changes microbiological response: eradicated. Outcome assessed on day 21 compared with oral monotherapy (very low certainty).

1 finding from 1 review