Findings

What do systematic reviews say?

4,411 questions · 5,986 findings · 226 reviews · Oral Health

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No studies found 1,305 · 21.8%GRADE not reported 2,988 · 49.9%Very low 1,030 · 17.2%Low 476 · 8%Moderate 156 · 2.6%High 31 · 0.5%

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Vibrational appliance with fixed appliances vs Fixed appliances

Time to alignment · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Vibrational appliance with fixed appliances showed no clear difference in time to alignment (days) compared with fixed appliances only / no vibrational appliance (control); GRADE not reported.

1 finding from 1 review

Orthodontic treatment for crowded teeth in children 2021 · Cochrane All outcomes
alignment
MD -3.70 [-26.29, 18.89]
2 studies
GRADE not reported

ARP with demineralised bone matrix, single particle size vs ARP with demineralised bone matrix, multiple particle size

Implant failure rate · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes
6 months
Outcome not reported
0 studies
No studies found

Digital radiographs vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…

1 finding from 1 review

Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomes
Up to 3 months between index test and reference standard (in vivo studies)
Sensitivity 0.49 [0.42, 0.56]
40 studies
GRADE not reported

CO2 laser (carbon dioxide) vs Placebo (placebo laser or placebo agent) or no treatment

Outcome not reported · Patients aged above 12 years with self-reported tooth hypersensitivity confirmed on clinical evaluation

The review found no eligible studies for this question.

1 finding from 1 review

Laser therapy for dentinal hypersensitivity 2021 · Cochrane All outcomes
We did not find any eligible study to evaluate erbium:yttrium-aluminum-garnet (Er:YAG) or carbon dioxide (CO2) laser compared with placebo/no treatment.
0 studies
No studies found

Haas expander anchored on deciduous second molars vs Haas expander anchored on permanent first molars

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

1 finding from 1 review

Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
after 5-month retention period
Ugolini 2015: deciduous 4.3 mm vs permanent 5.8 mm; P<0.01 (favours permanent-molar anchorage)
1 study
GRADE not reported

Hyrax with conventional expansion screw vs Hyrax with NiTi memory expansion screw

Molar expansion · Children and adults with a posterior crossbite, without a Class III skeletal relationship, cleft lip or palate (or both), or other…

1 finding from 1 review

Orthodontic treatment for posterior crossbites 2021 · Cochrane All outcomes
after 6-month retention period
Halicioglu 2014: conventional Hyrax 8.41 (SD 2.09) mm vs NiTi Hyrax 8.94 (SD 1.73) mm; no statistically significant differences for any outcome
1 study
GRADE not reported

Non-selective carious tissue removal and conventional restoration (CR) vs Selective carious tissue removal (selective excavation, SE)

Lesion progression · Children and/or adults with permanent or primary teeth, vital (sensitive) pulps, and cavitated or dentine carious lesions conventionally…

1 finding from 1 review

Interventions for treating cavitated or dentine carious lesions 2021 · Cochrane All outcomes
Cavitated but not deep lesions, primary dentition
Lesion progression reported narratively: Ribeiro 1999 found 6/24 lesions progressed after 12 months; not pooled and not GRADE-rated.
1 study
GRADE not reported

Mineral trioxide aggregate (MTA) vs Super ethoxybenzoic acid (Super-EBA)

Adverse events · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

The review found no eligible studies for this question.

1 finding from 1 review

Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
Adverse events: outcome was not assessed by the included studies
0 studies
No studies found

Radiographic imaging methods (any: analogue radiographs, digital radiographs, or CBCT) vs Reference standard (histology, excavation, or enhanced visual examination)

Diagnostic accuracy on surfaces with pit and fissure sealants · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…

The review found no eligible studies for this question.

1 finding from 1 review

Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomes
Up to 3 months between index test and reference standard (in vivo studies) · Pit and fissure sealants
Pre-specified heterogeneity investigation of surfaces with pit and fissure sealants: no study reported the inclusion of sealants that would allow evaluation of early caries lesions.
0 studies
No studies found

Self-ligating brackets vs Conventional brackets

Amount of crowding (lower incisor crowding) at 10 weeks · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether self-ligating brackets changes amount of crowding (lower incisor crowding) at 10 weeks compared with conventional brackets (very low certainty).

1 finding from 1 review

Orthodontic treatment for crowded teeth in children 2021 · Cochrane All outcomes
10 weeks
MD -0.40 [-0.93, 0.13]
1 study · 60 participants
Very low

ARP with alloplast vs ARP with xenograft

Aesthetic outcomes of future prosthodontic rehabilitation · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes
6 to 8 months
Outcome not reported
0 studies
No studies found

Rubber dam vs Isolite system

Clinical evaluation of restoration's quality · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)

The review found no eligible studies for this question.

1 finding from 1 review

Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
no estimate extracted
0 studies
No studies found

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

Toxicity / adverse effects (harms) of chemotherapy · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer

1 finding from 1 review

Interventions for the treatment of oral cavity and oropharyngeal cancer: chemotherapy 2021 · Cochrane All outcomes
Harms/toxicity were planned but very little quantitative data suitable for analysis were found; toxicity reported narratively and not quantified or GRADE-rated.
Studies not reported
GRADE not reported

Mineral trioxide aggregate (MTA) vs Root repair material (RRM)

Adverse events · Patients needing retrograde filling in root canal therapy (orthograde root canal filling or retreatment not possible; periapical surgery…

The review found no eligible studies for this question.

1 finding from 1 review

Materials for retrograde filling in root canal therapy 2021 · Cochrane All outcomes
Adverse events: outcome was not assessed by the included studies
0 studies
No studies found

Rubber dam vs Isolite system

Adverse events · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)

The review found no eligible studies for this question.

1 finding from 1 review

Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
treatment phase
no estimate extracted
0 studies
No studies found

Near-infrared (NIR) transillumination vs Reference standard (histology, excavation, radiographs/microCT, or tooth separation)

Specificity for detection and diagnosis of early (enamel) caries · Asymptomatic children, adolescents, or adults presenting for clinical examination (in vivo studies), or extracted teeth of children or…

1 finding from 1 review

Transillumination and optical coherence tomography for the detection and diagnosis of enamel caries 2021 · Cochrane All outcomes
Up to 3 months between index test and reference standard (in vivo; in vitro no limit if stored appropriately)
Specificity 0.86 [0.80, 0.91]
5 studies
GRADE not reported

Intensive periodontal treatment (subgingival SRP with or without other periodontal treatment) vs Supra-gingival scaling

Percentage of bleeding on probing (BOP) · Adults (any age/sex) with chronic periodontitis (>=5 teeth remaining; PPD >4 mm), with or without hypertension

Intensive periodontal treatment (subgingival SRP with or without… led to lower bleeding on probing (BOP) compared with supra-gingival scaling; GRADE not reported.

2 findings from 1 review

Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
Long term · People diagnosed with periodontitis
MD -0.40 [-0.45, -0.35]
1 study
GRADE not reported
Effect of periodontal treatments on blood pressure 2021 · Cochrane All outcomes
Short term · People diagnosed with periodontitis
MD -0.42 [-0.47, -0.37]
1 study
GRADE not reported

Digital radiographs vs Reference standard (histology, excavation, or enhanced visual examination)

1 finding from 1 review

Imaging modalities to inform the detection and diagnosis of early caries 2021 · Cochrane All outcomes
Up to 3 months between index test and reference standard (in vivo studies)
Specificity 0.87 [0.82, 0.91]
40 studies
GRADE not reported

ARP with alloplast plus barrier membrane vs ARP with alloplast without membrane

Complications (e.g. discomfort, pain and swelling) · Adults aged 18 years or older, in good general health (including well-controlled systemic disease), requiring extraction of one or more…

1 finding from 1 review

Interventions for replacing missing teeth: alveolar ridge preservation techniques for dental implant site development 2021 · Cochrane All outcomes
9 months
Fibrous adhesions at the cervical part of previously preserved sockets were observed in 2 participants (Brkovic 2012)
1 study · 20 participants
Very low

Rubber dam isolation and moisture control (alone or with saliva aspiration) vs Cotton rolls (with or without saliva aspiration)

Adverse events · Dental patients undergoing direct or indirect restorative treatment (no age or gender restriction)

The review found no eligible studies for this question.

1 finding from 1 review

Rubber dam isolation for restorative treatment in dental patients 2021 · Cochrane All outcomes
treatment phase
Adverse events | Outcome not reported
0 studies
No studies found