Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,227 questions · 2,562 findings · 156 reviews · Oral Health

No studies found 297 · 11.6%GRADE not reported 1,616 · 63.1%Very low 405 · 15.8%Low 144 · 5.6%Moderate 81 · 3.2%High 19 · 0.7%

Single-stage alginate impression (simplified method) vs Two stage-two step zinc-oxide eugenol (ZoE) traditional method

Oral health-related quality of life · Completely edentulous people

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step zinc-oxide eugenol (ZoE) traditional method (very low certainty).

1 finding from 1 review

Alginate (two stage-two step final/wash impression) vs Silicone elastomer (two stage-two step)

Oral health-related quality of life · Completely edentulous people

Alginate (two stage-two step final/wash impression) may leads to higher participant-reported oral health-related quality of life… compared with silicone elastomer (two stage-two step) (low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) + bone graft (BG) vs OFD + BG (open flap debridement + bone graft)

Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

The review found no eligible studies for this question.

1 finding from 1 review

Single-stage alginate impression (simplified method) vs Two stage-two step elastomer (silicone, polysulfide, or polyether) conventional method

Oral health-related quality of life · Completely edentulous people

It is very uncertain whether single-stage alginate impression (simplified method) changes participant-reported oral health-related quality of life (OHIP-EDENT) compared with two stage-two step elastomer (silicone, polysulfide, or polyether)… (very low certainty).

1 finding from 1 review

Routine scale and polish every 6 months vs Routine scale and polish every 12 months

Participant satisfaction (perceived oral cleanliness) · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

It is very uncertain whether routine scale and polish every 6 months changes participant satisfaction (perceived oral cleanliness) compared with routine scale and polish every 12 months (very low certainty).

1 finding from 1 review

Autologous platelet concentrates (APC) + open flap debridement (OFD) vs Open flap debridement (access flap surgery)

Oral health-related quality of life · Patients affected by infrabony defects requiring surgical treatment, regardless of their age or gender

The review found no eligible studies for this question.

1 finding from 1 review

Routine scale and polish at a fixed interval vs No scheduled scale and polish treatment

Oral health-related quality of life · Dentate adults without severe periodontitis, regularly attending for dental care in primary care (UK general dental practice)

Planned, regular routine scale and polish (6-monthly; 12-monthly… showed no clear difference in oral health-related quality of life (OHIP-14) compared with no scheduled scale and polish treatment (high certainty).

1 finding from 1 review

Selenium vs no intervention

Quality of life and other oral related symptoms (loss of taste, dysphagia) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Pilocarpine vs no treatment/placebo

Other oral related symptoms (oral discomfort, eating difficulty, mucosal pain, oral complications) · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Antimicrobial lozenge vs placebo

Quality of life and other oral related symptoms · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Fluoride mouthrinse (any fluoride agent, concentration, volume, frequency or technique; swished and expectorated, not swallowed) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less
1 finding from 1 review

Selective or stepwise carious tissue removal vs Non-selective or complete carious tissue removal

Temporal change in the proportion of dentists utilizing SE/SW · Dentists managing deep carious lesions in permanent vital teeth

The proportion of dentists choosing selective or stepwise removal rose significantly over time, by about 1.6% per calendar year (meta-regression, p<0.05), a trend the authors described as borderline (ungraded).

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Mucosal irritation / oral soft tissue allergic reaction (signs of sensitivity) · Children and adolescents aged 16 years or less

The review found no eligible studies for this question.

1 finding from 1 review

Pilocarpine vs placebo

Other oral symptoms (oral discomfort, dysphonia) · Patients with radiation-induced salivary gland dysfunction
1 finding from 1 review

Vitamin D vs placebo or control

Femoral neck bone mineral density (FN-BMD) · Older or community-dwelling adults

Meta-analysis of randomised trials of vitamin D supplementation for Bone mineral density in femoral neck, Community-dwelling adults: WMD 1.10 (95% CI 0.40 to 1.90), statistically significant. Umbrella review outcome-level evidence grade: Suggestive.

1 finding from 1 review

Fluoride varnish vs placebo or no treatment

Adverse effects / specific side effects (oral allergic reactions, mucosal irritation, adverse symptoms such as nausea, gagging, vomiting) · Children and adolescents aged 16 years or less
1 finding from 1 review

Carboxymethylcellulose (CMC) spray vs Placebo (spray base without CMC / water)

Dry mouth (xerostomia) · Adults seeking treatment for the symptom of dry mouth (xerostomia) due to any cause (e.g. medication, Sjogren's syndrome, radiotherapy,…
1 finding from 1 review
  • Donatsky 1982 (crossover, n=15, Sjogren's syndrome): CMC spray had a similar effect on oral dryness to the spray base, but was more effective than water. Paired crossover data not presented; effect size not estimable.
    1 study · 15 participants
    GRADE not reported