Incidence of bleeding events · Adult patients with myelodysplastic syndromes and thrombocytopenia
Thrombopoietin mimetics probably leads to lower incidence of bleeding events compared with placebo (moderate certainty).
1 finding from 1 review
Blood transfusion requirements · Adult patients with myelodysplastic syndromes and thrombocytopenia
Thrombopoietin mimetics showed no clear difference in transfusion requirement compared with placebo (low certainty).
1 finding from 1 review
Health‐related quality of life · Adult patients with myelodysplastic syndromes and thrombocytopenia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
All adverse events · Adult patients with myelodysplastic syndromes and thrombocytopenia
Thrombopoietin mimetics showed no clear difference in all adverse events compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · Adult patients with myelodysplastic syndromes and thrombocytopenia
It is very uncertain whether thrombopoietin mimetics changes serious adverse events compared with placebo (very low certainty).
1 finding from 1 review
Function (overall) Various tools · adults (aged ≥ 16 years) with acute middle third clavicle fractures
Intramedullary fixation may leads to higher function or disability (overall) Various tools (Constant score and… compared with open reduction and internal fixation with plate (low certainty).
1 finding from 1 review
Pain ‐ using the section of Constant score Scale from 0 to 15; with 15 being the best positive score · adults (aged ≥ 16 years) with acute middle third clavicle fractures
It is very uncertain whether intramedullary fixation changes pain ‐ using the section of Constant score Scale from 0 to 15; with… compared with open reduction and internal fixation with plate (very low certainty).
1 finding from 1 review
Treatment failure (participants who have a non‐routine secondary surgical intervention) ‐ Overall treatment failure · adults (aged ≥ 16 years) with acute middle third clavicle fractures
It is very uncertain whether intramedullary fixation changes treatment failure (participants who have a non‐routine secondary… compared with open reduction and internal fixation with plate (very low certainty).
1 finding from 1 review
Clinical healing ‐ time to clinical/radiographic fracture consolidation (weeks) · adults (aged ≥ 16 years) with acute middle third clavicle fractures
It is very uncertain whether intramedullary fixation changes clinical healing ‐ time to clinical/radiographic fracture… compared with open reduction and internal fixation with plate (very low certainty).
1 finding from 1 review
Adverse events ‐ total of adverse events (various: mainly infection; cosmetic result ‐ e.g. prominent metalwork ‐ and symptomatic hardware) · adults (aged ≥ 16 years) with acute middle third clavicle fractures
It is very uncertain whether intramedullary fixation changes adverse events ‐ total of adverse events (various: mainly infection;… compared with open reduction and internal fixation with plate (very low certainty).
1 finding from 1 review
Quality of life ‐ not measured · adults (aged ≥ 16 years) with acute middle third clavicle fractures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Return to previous activities ‐ not measured · adults (aged ≥ 16 years) with acute middle third clavicle fractures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of Life: SF‐36 scale from 0 to 100 (higher scores = better outcome) · adults with tibial plateau fracture (Schatzker types V or VI)
1 finding from 1 review
Function Standardised scale with positive score indicating a better outcome. Scale from 0 (worst) to 100 (best). · adults with tibial plateau fracture (Schatzker types V or VI)
1 finding from 1 review
Physical function · adults with tibial plateau fracture (Schatzker types V or VI)
1 finding from 1 review
Adverse eventse · adults with tibial plateau fracture (Schatzker types V or VI)
It is very uncertain whether circular external fixation with limited internal fixation (hybrid… changes adverse eventse compared with standard open reduction internal fixation (very low certainty).
1 finding from 1 review
WOMAC Pain subscale from 0 to 100c (higher scores indicating greater function) · adults with tibial plateau fracture (Schatzker types V or VI)
1 finding from 1 review
Knee total range of motion (degrees) · adults with tibial plateau fracture (Schatzker types V or VI)
1 finding from 1 review
Return to activity · adults with tibial plateau fracture (Schatzker types V or VI)
It is very uncertain whether circular external fixation with limited internal fixation (hybrid… changes return to pre‐injury activity level compared with standard open reduction internal fixation (very low certainty).
1 finding from 1 review
Pain during activity (short‐term) · patients with patellofemoral pain syndrome (symptoms > 4 weeks (1 study); symptoms > 6 weeks (1 study); symptoms > 8 weeks (1 study); not…
It is very uncertain whether closed kinetic chain exercises changes pain during activity (short‐term) VAS (0 to 10; higher scores mean… compared with open kinetic chain exercises (very low certainty).
1 finding from 1 review