Findings

What do systematic reviews say?

970 questions · 979 findings · 135 reviews

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No studies found 182 · 18.6%GRADE not reported 84 · 8.6%Very low 165 · 16.9%Low 311 · 31.8%Moderate 163 · 16.6%High 74 · 7.6%

Intervention not reported

Death (all cause) · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention showed no clear difference in death (all cause) (low certainty).

1 finding from 1 review

Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV 2012 · Cochrane Headline outcomes only
RR 0.5 [0.05, 5.46]
1 study · 487 participants
Low

Intervention not reported

Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 400 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention may leads to higher proportion of patients achieving and maintaining undetectable viral… (low certainty).

1 finding from 1 review

Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV 2012 · Cochrane Headline outcomes only
RR 1.16
1 study · 487 participants
Low

Intervention not reported

Proportion of patients achieving and maintaining undetectable viral load, e.g. less than 50 copies/ml · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The intervention may leads to higher proportion of patients achieving and maintaining undetectable viral… (low certainty).

1 finding from 1 review

Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV 2012 · Cochrane Headline outcomes only
RR 1.13 [1.02, 1.25]
1 study · 487 participants
Low

Intervention not reported

CD4+ count · HIV infected adults who meet the WHO criteria for commencing antiretroviral treatment.

The review found no eligible studies for this question.

1 finding from 1 review

Effectiveness and safety of first-line tenofovir + emtricitabine + efavirenz for patients with HIV 2012 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pulmonary Methotrexate pneumonitis · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Moderate

Intervention not reported

Hepatic Liver histology/hepatic enzyme abnormalities2 · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 272 participants
Low

Intervention not reported

Renal Glomerular and tubular injury · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 30 participants
Low

Intervention not reported

Haematological Thrombocytopenia · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 1 participants
Moderate

Intervention not reported

Withdrawal due to adverse events Methotrexate discontinuation · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 632 participants
Low

Intervention not reported

All adverse events · patients with inflammatory arthritis on methotrexate

1 finding from 1 review

Safety of non‐steroidal anti‐inflammatory drugs, including aspirin and paracetamol (acetaminophen) in people receiving… 2011 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 283 participants
Moderate