Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

INTENSIVE CASE MANAGEMENT vs usual care

Adverse event: 1b. Death ‐ suicide ‐ by long term · people with severe mental disorders

Intensive Case Management showed no clear difference in adverse event: 1b. Death ‐ suicide ‐ by long term compared with standard care (low certainty).

1 finding from 1 review

INTENSIVE CASE MANAGEMENT vs usual care

Social functioning: 2. Employment status (various measurements) ‐ by long term ‐ not employed at the end of the trial · people with severe mental disorders

It is very uncertain whether intensive Case Management changes social functioning: 2. Employment status (various measurements) ‐ by… compared with standard care (very low certainty).

1 finding from 1 review

Combinations of antipsychotic drugs vs single antipsychotic drugs

Clinical response: No clinically important response ‐ as defined by each of the studies · schizophrenia or related disorders

It is very uncertain whether combinations of antipsychotic drugs changes clinical response: No clinically important response ‐ as defined by… compared with single antipsychotic drugs (very low certainty).

1 finding from 1 review

Combinations of antipsychotic drugs vs single antipsychotic drugs

Adverse events: Serious event or requiring discontinuation · schizophrenia or related disorders

It is very uncertain whether combinations of antipsychotic drugs changes adverse events: Serious event or requiring discontinuation compared with single antipsychotic drugs (very low certainty).

1 finding from 1 review

HALOPERIDOL vs ARIPIPRAZOLE

Global outcome ‐ need for benzodiazepine during 24 hours · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcomes: need for benzodiazepine 2 compared with OTHER ANTIPSYCHOTIC: a. ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

HALOPERIDOL vs COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE

Global outcome: general ‐ no improvement · patients with psychosis‐induced aggression or agitation

It is very uncertain whether HALOPERIDOL changes global outcome: general ‐ no overall improvement compared with COMBINATIONS: a. HALOPERIDOL + LEVOMEPROMAZINE (very low certainty).

1 finding from 1 review