Intervention not reported
ACQ responders at 6 months ‐ HD TRIPLE vs MD‐ICS/LABA№ of participants: 1916(2 RCTs)
It is very uncertain whether the intervention changes ACQ responders at 6 months ‐ HD TRIPLE vs MD‐ICS/LABA№ of… (very low certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 6 months ‐ MD TRIPLE vs HD‐ICS/LABA№ of participants: 2480(2 RCTs)
The intervention showed no clear difference in ACQ responders at 6 months ‐ MD TRIPLE vs HD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 6 months ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 4818(4 RCTs)
The intervention probably leads to higher ACQ responders at 6 months ‐ HD TRIPLE vs HD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 6 months ‐ HD TRIPLE vs MD TRIPLE№ of participants: 2821(3 RCTs)
The intervention showed no clear difference in ACQ responders at 6 months ‐ HD TRIPLE vs MD TRIPLE№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 6 months ‐ TRIPLE vs DUAL№ of participants: 7881(5 RCTs)
The intervention may leads to higher ACQ responders at 6 months ‐ TRIPLE vs DUAL№ of participants: 7881(5… (low certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of participants: 2817(2 RCTs)
The intervention showed no clear difference in ACQ responders at 12 months ‐ HD‐ICS/LABA vs MD‐ICS/LABA№ of… (low certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ MD TRIPLE vs MD‐ICS/LABA№ of participants: 2222(2 RCTs)
The intervention showed no clear difference in ACQ responders at 12 months ‐ MD TRIPLE vs MD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ HD TRIPLE vs MD‐ICS/LABA№ of participants: 1088(1 RCT)
The intervention probably leads to higher ACQ responders at 12 months ‐ HD TRIPLE vs MD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ MD TRIPLE vs HD‐ICS/LABA№ of participants: 1631(1 RCT)
The intervention showed no clear difference in ACQ responders at 12 months ‐ MD TRIPLE vs HD‐ICS/LABA№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
Severe exacerbations ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 1727(2 RCTs)
The intervention showed no clear difference in severe exacerbations ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants:… (moderate certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ HD TRIPLE vs HD‐ICS/LABA№ of participants: 3982(3 RCTs)
It is very uncertain whether the intervention changes ACQ responders at 12 months ‐ HD TRIPLE vs HD‐ICS/LABA№ of… (very low certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ HD TRIPLE vs MD TRIPLE№ of participants: 1089(1 RCT)
The intervention probably leads to higher ACQ responders at 12 months ‐ HD TRIPLE vs MD TRIPLE№ of… (moderate certainty).
1 finding from 1 review
Intervention not reported
ACQ responders at 12 months ‐ TRIPLE vs DUAL№ of participants: 6204(4 RCTs)
It is very uncertain whether the intervention changes ACQ responders at 12 months ‐ TRIPLE vs DUAL№ of participants:… (very low certainty).
1 finding from 1 review
Intervention not reported
Total studies: 13 RCTs Total Participants: 144476 · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
HD‐ICS/LABA (Direct evidence; 8 RCTs; 7511 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
MD‐TRIPLE (Direct evidence; 3 RCTs; 3187 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
HD‐TRIPLE (Direct evidence; 2 RCT; 2039 participants) · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
1 finding from 1 review
Intervention not reported
MD‐ICS/LABA · Adolescents and adults with symptomatic asthma Interventions: HD‐ICS/LABA, MD‐TRIPLE, HD‐TRIPLE Comparator (reference): Medium‐Dose…
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Outcome№ of participants(studies)
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
All cause SAEs ‐ HD‐ICS/LABA vs MD‐ICS LABA№ of participants: 7511(8 RCTs)
The intervention showed no clear difference in all cause SAEs ‐ HD‐ICS/LABA vs MD‐ICS LABA№ of participants: 7511(8… (high certainty).
1 finding from 1 review