Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/40 at end of treatment; oral corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/40 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after treatment; topical corticosteroids · people with traumatic hyphema

It is very uncertain whether systemic or topical corticosteroids changes short‐term visual acuity between 20/20 and 20/40 ≤ 2 weeks after… compared with placebo or control treatment (very low certainty).

1 finding from 1 review

Systemic or topical corticosteroids vs placebo or control

Final visual acuity between 20/20 and 20/25 at end of treatment; topical corticosteroids · people with traumatic hyphema

Systemic or topical corticosteroids showed no clear difference in final visual acuity between 20/20 and 20/25 at end of treatment;… compared with placebo or control treatment (low certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Long‐term visual acuity 20/40 or better > 2 months after treatment · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in long‐term visual acuity 20/40 or better > 2 months after treatment compared with placebo (low certainty).

1 finding from 1 review

Other pharmaceutical agents vs placebo or control

Risk of secondary hemorrhage; conjugated estrogen · people with traumatic hyphema

Other pharmaceutical agents showed no clear difference in risk of secondary hemorrhage; conjugated estrogen compared with placebo or other control interventions (moderate certainty).

1 finding from 1 review

Other pharmaceutical agents vs placebo or control

Risk of secondary hemorrhage; cycloplegics · people with traumatic hyphema

It is very uncertain whether other pharmaceutical agents changes risk of secondary hemorrhage; cycloplegics compared with placebo or other control interventions (very low certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Final visual acuity 20/40 or better at resolution of hyphema · people with traumatic hyphema

Systemic aminocaproic acid showed no clear difference in final visual acuity 20/40 or better at resolution of hyphema compared with placebo (low certainty).

1 finding from 1 review

Systemic aminocaproic acid vs placebo

Adverse event nausea and vomiting (0 to 24 hours) · people with traumatic hyphema

Systemic aminocaproic acid probably leads to higher adverse effects: nausea or vomiting compared with placebo (moderate certainty).

1 finding from 1 review

Topical aminocaproic acid vs placebo

Short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment · people with traumatic hyphema

Topical aminocaproic acid showed no clear difference in short‐term visual acuity 20/40 or better ≤ 2 weeks after treatment compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Recombinant activated factor VII vs placebo/open control

Death or dependence (mRS 4 to 6) at day 90 · adults with acute spontaneous intracerebral haemorrhage

Summary of findings table ‐ Recombinant activated factor VII showed no clear difference in death or dependence (mRS 4–6) compared with placebo/open control (low certainty).

1 finding from 1 review