Findings

What do systematic reviews say?

4,783 questions · 10,022 findings · 882 reviews

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No studies found 2,100 · 21%GRADE not reported 1,013 · 10.1%Very low 2,237 · 22.3%Low 2,514 · 25.1%Moderate 1,709 · 17.1%High 449 · 4.5%

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Preoperative radiotherapy vs surgery

Sphincter preservation ( · People with localised rectal carcinoma

Preoperative radiotherapy showed no clear difference in sphincter preservation ( compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
RR 0.99 [0.94, 1.04]
3 studies · 4379 participants
Low

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ sepsis (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ sepsis (within 30 days after surgery) compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
RR 1.25 [1.04, 1.52]
2 studies · 2698 participants
Low

Preoperative radiotherapy vs surgery

Postoperative morbidity ‐ surgical complications (within 30 days after surgery) · People with localised rectal carcinoma

Preoperative radiotherapy may leads to higher postoperative morbidity ‐ surgical complications (within 30 days… compared with surgery alone (low certainty).

1 finding from 1 review

Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
RR 1.2 [1.01, 1.42]
2 studies · 2698 participants
Low

Preoperative radiotherapy vs surgery

Quality of life ( · People with localised rectal carcinoma

1 finding from 1 review

Preoperative radiotherapy and curative surgery for the management of localised rectal carcinoma 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 3211 participants
Low

Daily conventionally fractionated radiotherapy vs supportive care

Overall survival · high‐grade glioma

Daily conventionally fractionated radiotherapy probably leads to higher overall survival compared with no radiotherapy (supportive care alone) (moderate certainty).

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
HR 2.01 [1.58, 2.55]
4 studies · 397 participants
Moderate

Daily conventionally fractionated radiotherapy vs supportive care

Adverse effects · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 289 participants
GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

Progression‐free survival · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

Quality of life · high‐grade glioma

1 finding from 1 review

External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 81 participants
GRADE not reported

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Cardiac T2* value · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 191 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

MIC · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 138 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

LVEF (echocardiography) · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 136 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Ferritin (µg/L) · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 187 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Liver T2* value · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 127 participants
Low

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

LIC · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 123 participants
Moderate

Amlodipine plus standard iron chelation therapy vs standard chelation therapy with or without placebo

Adverse events · or population: people with transfusion‐dependent beta thalassaemia

1 finding from 1 review

Calcium channel blockers for preventing cardiomyopathy due to iron overload in people with transfusion‐dependent beta… 2023 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 234 participants
Very low

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants cleared or almost cleared ‐ · chronic palmoplantar pustulosis

It is very uncertain whether etretinate with PUVA therapy as co‐intervention changes proportion of participants cleared or almost cleared in the short… compared with placebo with PUVA therapy (very low certainty).

1 finding from 1 review

Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
RR 1.91 [1.04, 3.5]
1 study · 20 participants
Very low

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants with adverse effects serious or severe enough to have caused withdrawal ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants with at least 50% improvement in their quality of life ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants achieving a 50% reduction in disease severity ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Etretinate with PUVA therapy as co‐intervention vs placebo with PUVA therapy

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for chronic palmoplantar pustulosis 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found