Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,005 questions · 1,053 findings · 151 reviews · Headline outcomes only

No studies found 275 · 26.1%GRADE not reported 150 · 14.2%Very low 271 · 25.7%Low 215 · 20.4%Moderate 105 · 10%High 37 · 3.5%

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

Mortality within the longest · patients with vitamin K antagonist‐induced bleeding requiring acute intervention

It is very uncertain whether prothrombin complex concentrate changes overall mortality ‐ longest compared with any comparator (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Prothrombin complex concentrates vs any comparator

Number of new occurrences of RBC transfusion · patients with vitamin K antagonist‐induced bleeding requiring acute intervention

It is very uncertain whether prothrombin complex concentrate changes number of new occurrences of RBC transfusion compared with any comparator (very low certainty).

1 finding from 1 review

Intervention not reported

Arterial thromboembolic events ( · any patients with conditions outside the marketing license for the intervention, particularly those at risk of bleeding or those whose…

The intervention probably leads to higher arterial thromboembolic events ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of patients transfused ( · any patients with conditions outside the marketing license for the intervention, particularly those at risk of bleeding or those whose…

The intervention showed no clear difference in number of patients transfused ( (low certainty).

1 finding from 1 review

Intervention not reported

Total thromboembolic events ( · any patients with conditions outside the marketing license for the intervention, particularly those at risk of bleeding or those whose…

The intervention showed no clear difference in total thromboembolic events ( (moderate certainty).

1 finding from 1 review

Intervention not reported

Numbers of patients with reduced bleeding ( · any patients with conditions outside the marketing license for the intervention, particularly those at risk of bleeding or those whose…

The intervention showed no clear difference in numbers of patients with reduced bleeding ( (low certainty).

1 finding from 1 review

Intervention not reported

Total thromboembolic events ( · any patients with conditions outside the marketing license for the intervention, particularly those at risk of bleeding or those whose…

The intervention showed no clear difference in total thromboembolic events ( (moderate certainty).

1 finding from 1 review

Attention deficit hyperactivity disorder (ADHD)‐related drugs vs placebo

Aggression · participants (any age) with a clinical diagnosis of ASD who have displayed one or more unwanted or challenging behaviours at baseline…

The review found no eligible studies for this question.

1 finding from 1 review