Cochrane · systematic review · CD005011
Recombinant factor VIIa for the prevention and treatment of bleeding in patients without haemophilia
Simpson, E, Lin, Y, Stanworth, S, et al. · Cochrane Database of Systematic Reviews · 2012 · Cochrane Library
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
10
current version
GRADE rated
10
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 5 · 50%Moderate 5 · 50%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Show all 3 versionsComparison
Population: any patients with conditions outside the marketing license for the intervention, particularly those at risk of bleeding or those whose bleeding cannot be controlled by other means
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Death ( | RR 1.04 [0.55, 1.97] | 15 studies · 1219 participants | Moderate Downgraded: imprecision, inconsistency, publication bias |
Total operative and perioperative blood loss (mL) ( | no estimate extracted | 10 studies · 707 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Red cell transfusion requirements (mL) ( | no estimate extracted | 12 studies · 774 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Number of patients transfused ( | RR 0.85 [0.72, 1.01] | 8 studies · 868 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Total thromboembolic events ( | RR 1.35 [0.82, 2.25] | 13 studies · 1159 participants | Moderate Downgraded: imprecision, inconsistency, publication bias |
Death ( | RR 0.91 [0.78, 1.06] | 13 studies · 2856 participants | Moderate Downgraded: imprecision, inconsistency, publication bias |
Numbers of patients with reduced bleeding ( | RR 0.95 [0.88, 1.03] | 4 studies · 616 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Red cell transfusion requirements (mL) ( | no estimate extracted | 5 studies · 911 participants | Low Downgraded: imprecision, inconsistency, publication bias |
Total thromboembolic events ( | RR 1.14 [0.89, 1.47] | 13 studies · 2873 participants | Moderate Downgraded: imprecision, inconsistency, publication bias |
Arterial thromboembolic events ( | RR 1.45 [1.02, 2.05] | 25 studies · 3849 participants | Moderate Downgraded: imprecision, inconsistency, publication bias |