Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,171 questions · 1,373 findings · 60 reviews · Dental caries

No studies found 282 · 20.5%GRADE not reported 606 · 44.1%Very low 257 · 18.7%Low 160 · 11.7%Moderate 66 · 4.8%High 2 · 0.1%

Chlorhexidine toothpaste vs Placebo or no intervention (including routine care)

Outcome not reported · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

Dental caries in permanent teeth · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)
1 finding from 1 review
  • Water fluoridation for the prevention of dental caries 2015 · Cochrane All outcomes
    Follow-up 3 years
    Insufficient evidence to determine the effect of the cessation of water fluoridation on caries. One study (Maupome 2001), at high risk of bias, over 3 years found no increase in caries in the fluoride-ended group…
    1 study · 9249 participants
    Very low

Resin sealant (with or without flossing advice) vs Flossing advice (non-invasive control)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Resin sealant (with or without flossing advice) led to lower caries (lesion) progression (radiographic) compared with flossing advice (non-invasive control); GRADE not reported.

1 finding from 1 review

Single full-coverage metal-ceramic crown over composite core and post vs Direct adhesive composite restoration with post (conventional filling, no crown)

Non-catastrophic failure of the restoration (requiring further treatment) · People with a permanent tooth that has undergone endodontic (root canal) treatment

It is very uncertain whether single full-coverage metal-ceramic crown over composite core and post changes non-catastrophic failure of the restoration (requiring further… compared with direct adhesive composite restoration with post (conventional… (very low certainty).

1 finding from 1 review

Xylitol lozenges (4.7 g/day) vs no treatment

Number of children with a caries increment · Children (permanent teeth; baseline 8 to 10 years)

Xylitol lozenges (4.7 g/day) showed no clear difference in number of children with a caries increment compared with no treatment; GRADE not reported.

1 finding from 1 review

Micro-invasive treatment (proximal sealing or resin infiltration) vs Conventional invasive treatment (restoration / drill and fill)

Outcome not reported · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine gel (0.12%) vs no treatment

Presence of new caries in the primary teeth · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

It is very uncertain whether chlorhexidine gel (0.12%) changes presence of new caries in the primary teeth compared with no treatment (very low certainty).

1 finding from 1 review

Preformed metal crown (fitted using the Hall Technique) vs Preformed metal crown (fitted using a conventional technique)

Outcome not reported · Children with decayed primary molar teeth

The review found no eligible studies for this question.

1 finding from 1 review
  • None of the included studies compared the effectiveness or safety of the Hall Technique versus the conventional technique of fitting a crown. No RCT evidence found.
    0 studies
    No studies found

Chlorhexidine varnish vs placebo or no treatment

Pain, quality of life, patient satisfaction or costs · Children and adolescents below 18 years at study start (included studies: children from birth to 15 years), with mixed, permanent or…

The review found no eligible studies for this question.

1 finding from 1 review

Fluoride gel (topically applied; operator- or self-applied; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

Caries increment in primary/deciduous teeth: decayed, (extraction indicated/missing) and filled teeth d(e/m)ft (prevented fraction) · Children with primary (deciduous) teeth (younger children)

The review found no eligible studies for this question.

1 finding from 1 review

Resin infiltration vs Non-invasive measures (fluoride varnish/toothpaste, flossing, oral hygiene instruction, sham/standard of care)

Caries (lesion) progression (radiographic) · Dentate children and adults with non-cavitated proximal caries lesions extending into enamel or dentine (not pulp) in primary or permanent…

Resin infiltration led to lower caries (lesion) progression (radiographic) compared with fluoride varnish, sham/placebo, or flossing advice (non-invasive…; GRADE not reported.

1 finding from 1 review

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

Disparities in caries across socioeconomic status (SES) · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

The review found no eligible studies for this question.

1 finding from 1 review

Hall technique vs Non-restorative caries treatment

Adverse events: gingival bleeding · Children with decayed primary molar teeth

It is very uncertain whether preformed metal crown (fitted using the Hall Technique) changes adverse events: gingival bleeding compared with non-restorative caries treatment (very low certainty).

1 finding from 1 review

Preformed metal crown (stainless steel), conventional technique vs Aesthetic crown (stainless steel with composite/white veneer), conventional technique

Adverse events: bone resorption · Children with decayed primary molar teeth
1 finding from 1 review
  • Preformed crowns for decayed primary molar teeth 2015 · Cochrane All outcomes
    Six months and four years
    Bone resorption: one case at six months in a tooth treated with a veneer crown; no bone resorption at either the veneer crown or stainless steel sites at four-year follow-up (Analysis 3.2).
    1 study · 11 participants
    Very low

Cessation of water fluoridation (fluoride removed from the water supply) vs Continued fluoridated water

Adverse effects · People of all ages in a previously fluoridated community (Maupome 2001: children with generally low caries experience)

The review found no eligible studies for this question.

1 finding from 1 review

Preformed metal crown (stainless steel), conventional technique vs Aesthetic crown (stainless steel with composite/white veneer), conventional technique

Adverse events: gingival bleeding · Children with decayed primary molar teeth
1 finding from 1 review
  • Preformed crowns for decayed primary molar teeth 2015 · Cochrane All outcomes
    Six months and four years
    At six months, none (0/11) of the PMC sites had gingival bleeding, but all (11/11) veneer sites had bleeding, 10 of which bled on probing; statistically significant (McNemar's test, P < 0.001). At four years, one case…
    1 study · 11 participants
    Very low

Initiation of water fluoridation (artificial or natural) vs Low/non-fluoridated water (0.4 ppm fluoride or less)

Caries in deciduous teeth (change in dmft) · People of all ages in a community setting; the included caries studies were all in children aged 3 to 16 years

Initiation of water fluoridation (artificial or natural) may leads to lower caries in deciduous teeth (change in dmft) compared with low/non-fluoridated water (0.4 ppm fluoride or less) (low certainty).

1 finding from 1 review