Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,085 questions · 1,232 findings · 66 reviews · All outcomes

No studies found 218 · 17.7%GRADE not reported 745 · 60.5%Very low 179 · 14.5%Low 65 · 5.3%Moderate 25 · 2%High 0 · 0%

Morphine vs Tricyclic antidepressant (nortriptyline)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine led to lower average pain scores (0-100 VAS) compared with tricyclic antidepressant (nortriptyline); GRADE not reported.

1 finding from 1 review

Clotrimazole 50 mg (partially absorbed) vs Clotrimazole 10 mg (partially absorbed)

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Clotrimazole 50 mg (partially absorbed) led to higher mycological: eradication of oral candidiasis compared with clotrimazole 10 mg (partially absorbed); GRADE not reported.

1 finding from 1 review

GM-CSF vs povidone‐iodine

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Granulocyte macrophage-colony stimulating factor (GM-CSF) led to lower time to heal mucositis (days) compared with povidone iodine; GRADE not reported.

1 finding from 1 review

Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose)

Presence/absence of HSV oral lesions · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)

Prophylactic valaciclovir (lower dose) showed no clear difference in presence/absence of HSV oral lesions compared with prophylactic valaciclovir (higher dose); GRADE not reported.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Adverse drug reactions · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…
1 finding from 1 review
  • Only Goudot 2000 reported adverse reactions. Arthroscopy group: one transient frontal palsy (during 3 months); one cervico-facial oedema requiring prolonged intubation (12 hours). Arthrocentesis group: two severe…
    1 study · 62 participants
    GRADE not reported

Arthrocentesis and lavage vs Arthroscopy

Overall success (compound score combining pain and MIO) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage showed no clear difference in overall success (compound score combining pain and MIO) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose)

Viral isolates · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)
1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Temporomandibular joint tenderness · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

The review found no eligible studies for this question.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Deviation of the mandible · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

The review found no eligible studies for this question.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Pain (VAS) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage showed no clear difference in pain (VAS) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Prophylactic valaciclovir (lower dose) vs Prophylactic valaciclovir (higher dose)

Adverse effects · Patients being treated for cancer (acute leukaemia; chemotherapy or stem-cell transplantation)
1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Trismus / maximum mouth opening (mean) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage led to lower maximum incisal (mouth) opening (MIO) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Arthrocentesis and lavage vs Arthroscopy

Improvement in pain (proportion of participants improved/healed) · Adults with temporomandibular joint disorders (internal derangement; anterior disc displacement with or without reduction) whose symptoms…

Arthrocentesis and lavage showed no clear difference in improvement in pain (proportion of participants improved/healed) compared with arthroscopy; GRADE not reported.

1 finding from 1 review

Antifungal drugs partially absorbed from GI tract (miconazole, clotrimazole) vs placebo or no treatment

Systemic fungal infection · Patients with cancer receiving chemotherapy and/or radiotherapy

Antifungal drugs partially absorbed from GI tract (miconazole,… showed no clear difference in systemic fungal infection compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review