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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

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Review versions

2,206 questions in 117 reviews · Common Mental Disorders

current versions

No studies 387 · 17.5%Ungraded 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
MI therapy vs control Frequency of gambling ‐ comparisons at 0 to 3 months post‐treatment Lower scores indicate reduced financial loss from gambling, and thus positive outcomes1 · patients with pathological and problem gambling Psychological therapies for pathological and problem gambling (2012) · Cochrane	no estimate extracted	2 studies · 145 participants	Very low
Amitriptyline vs placebo Response to treatment At least 50% reduction of a depression scale (mainly Hamilton Depression Rating Scale) · adults with major depressive disorder Amitriptyline versus placebo for major depressive disorder (2012) · Cochrane	OR 2.64 [2.28, 3.06]	31 studies · 3228 participants	Moderate
Amitriptyline vs placebo Death due to suicide · adults with major depressive disorder Amitriptyline versus placebo for major depressive disorder (2012) · Cochrane	no estimate extracted	NR	No studies
Amitriptyline vs placebo Quality of life · adults with major depressive disorder Amitriptyline versus placebo for major depressive disorder (2012) · Cochrane	no estimate extracted	NR	No studies
Amitriptyline vs placebo Acceptability of treatment Drop‐out for any reason · adults with major depressive disorder Amitriptyline versus placebo for major depressive disorder (2012) · Cochrane	OR 0.71 [0.55, 0.93]	24 studies · 2400 participants	Very low
Amitriptyline vs placebo Overall tolerability Drop‐out due to adverse events · adults with major depressive disorder Amitriptyline versus placebo for major depressive disorder (2012) · Cochrane	OR 4.15 [2.71, 6.35]	19 studies · 2174 participants	Moderate