Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block
1 finding from 1 review
Postoperative pain intensity in the immediate postobturation period (up to 72 hours), continuous (VAS) · participants undergoing surgery with peripheral nerve block
3 findings from 1 review
no estimate extracted
5 studies · 257 participants
Very low
no estimate extracted
9 studies · 469 participants
Low
no estimate extracted
3 studies · 296 participants
Low
Duration of sensory block (we included all studies describing duration of sensory block regardless of how it was described) · participants undergoing surgery with peripheral nerve block
1 finding from 1 review
Incidence of serious adverse events (we used the NIH definition of adverse events. A serious event includes death, a life‐threatening event that requires hospitalization or prolonged hospitalization, disability or congenital anomaly) · participants undergoing surgery with peripheral nerve block
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Postextubation stridor (defined as any inspiratory sound or persistent barking, or presence of sternal or intercostal retractions postextubation) · Children up to eight years undergoing general anaesthesia
It is very uncertain whether cuffed changes postextubation stridor (defined as any inspiratory sound or… compared with uncuffed tubes (very low certainty).
1 finding from 1 review
Need for ETT exchange (defined as more than one attempt to arrive at the final endotracheal tube size) · Children up to eight years undergoing general anaesthesia
It is very uncertain whether cuffed changes need for ETT exchange (defined as more than one attempt to arrive at… compared with uncuffed tubes (very low certainty).
1 finding from 1 review
Need for tracheal re‐intubation for postoperative stridor (defined as the need to re‐intubate to assure oxygenation to deal with postextubation stridor) · Children up to eight years undergoing general anaesthesia
It is very uncertain whether cuffed changes need for tracheal re‐intubation for postoperative stridor (defined… compared with uncuffed tubes (very low certainty).
1 finding from 1 review
Need for epinephrine to treat stridor (defined as the need to use epinephrine to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia
It is very uncertain whether cuffed changes need for epinephrine to treat stridor (defined as the need to use… compared with uncuffed tubes (very low certainty).
1 finding from 1 review
Need for intensive care unit (ICU) admission to treat post extubation stridor (as defined by the trial authors) · Children up to eight years undergoing general anaesthesia
It is very uncertain whether cuffed changes need for intensive care unit (ICU) admission to treat post… compared with uncuffed tubes (very low certainty).
1 finding from 1 review
Cost of medical gas (described in the study by the hospital expenses for medical gases per participant in Euros) · Children up to eight years undergoing general anaesthesia
1 finding from 1 review
Need for corticosteroid to treat stridor (defined as the need to use corticosteroid to treat postextubation stridor) · Children up to eight years undergoing general anaesthesia
It is very uncertain whether cuffed changes need for corticosteroid to treat stridor (defined as the need to use… compared with uncuffed tubes (very low certainty).
1 finding from 1 review
Recovery timea from second twitch (T2) to train‐of‐four ratio (TOFR) > 0.9 (moderate block) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
1 finding from 1 review
Bradycardia · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
Sugammadex (any dose) probably leads to lower bradycardia compared with neostigmine (any dose) (moderate certainty).
1 finding from 1 review
Number of patients with postoperative nausea and vomiting (24 hours postoperatively) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
Sugammadex (any dose) may leads to lower PONV compared with neostigmine (any dose) (low certainty).
1 finding from 1 review
Overall signs of postoperative residual paralysis · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
Sugammadex (any dose) probably leads to lower overall signs of postoperative residual paralysis compared with neostigmine (any dose) (moderate certainty).
1 finding from 1 review
Risk of serious adverse eventsb · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
Sugammadex (any dose) showed no clear difference in risk of serious adverse eventsb compared with neostigmine (any dose) (low certainty).
1 finding from 1 review
Recovery timea from post‐tetanic count (PTC) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Risk of adverse events and serious adverse eventsb, bradycardia, PONV, and signs of residual neuromuscular blockade · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recovery timea from second twitch (T2) to train‐of‐four ratio (TOFR) > 0.9 (moderate block) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Recovery timea from post‐tetanic count (PTC 1 to 5) to train‐of‐four ratio (TOFR) > 0.9 (deep block) · Adult patients, ASA I‐IV, who received non‐depolarizing NMBAs
1 finding from 1 review