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Evidence found and GRADE certainty

3,234 questions · 3,357 findings · 396 reviews

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No studies found 803 · 23.9%GRADE not reported 270 · 8%Very low 757 · 22.5%Low 859 · 25.6%Moderate 486 · 14.5%High 182 · 5.4%

Vitamin A or retinoids (systemic or topical; incl. 13-cis-retinoic acid, acitretin) vs placebo or no treatment

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes
    4 to 12 months
    SoF 1, Safety of the intervention at 4 to 12 months: '3 studies (1 each evaluating topical acitretin, topical 13-cis-retinoic acid, 200,000 IU per week of vitamin A) found no adverse effects. Systemic 13-cis-retinoic…
    4 studies
    GRADE not reported

Parenteral nutrition with protein, fat, carbohydrates and branched‐chain amino acids vs 5% dextrose and normal saline

1‐year‐survival · adult patients after liver transplantation.

It is very uncertain whether parenteral nutrition with protein, fat, carbohydrates and… changes 1‐year‐survival compared with 5% dextrose and normal saline (very low certainty).

1 finding from 1 review

Parenteral nutrition with protein, fat, carbohydrates and branched‐chain amino acids vs 5% dextrose and normal saline

3‐year‐survival · adult patients after liver transplantation.

It is very uncertain whether parenteral nutrition with protein, fat, carbohydrates and… changes 3‐year‐survival compared with 5% dextrose and normal saline (very low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Cure: short‐term success · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics plus antibiotic lock solutions plus tissue… changes cure: short‐term success compared with systemic antibiotics plus antibiotic lock solutions plus heparin (very low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Cure: long‐term success · patients on maintenance HD with CRBSI

It is very uncertain whether systemic antibiotics plus antibiotic lock solutions plus tissue… changes cure: long‐term success compared with systemic antibiotics plus antibiotic lock solutions plus heparin (very low certainty).

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Stenosis or thrombosis of vascular access site after catheter removal · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Systemic antibiotics plus antibiotic lock solutions plus tissue plasminogen activator vs systemic antibiotics plus antibiotic lock solutions plus heparin

Development of antibiotic resistance · patients on maintenance HD with CRBSI

The review found no eligible studies for this question.

1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Percentage of bleeding on probing (BOP) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

It is very uncertain whether mechanical debridement plus local antimicrobial (minocycline… changes bleeding on probing (ratios) compared with mechanical debridement alone (very low certainty).

1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Adverse events · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)
1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Probing pocket depth (PPD/PD) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in pocket depth (mm) compared with mechanical debridement alone (low certainty).

1 finding from 1 review

Mechanical debridement plus local antimicrobial (minocycline microspheres or doxycycline gel) vs Mechanical debridement alone

Clinical attachment level (CAL) · Adults treated for periodontitis and receiving supportive periodontal therapy (SPT)

Mechanical debridement plus local antimicrobial (minocycline… showed no clear difference in clinical attachment level (mm) compared with mechanical debridement alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Contact immunotherapy (diphencyprone) + hair growth stimulants (minoxidil) vs contact immunotherapy (diphencyprone)

Short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of · adults with alopecia areata

It is very uncertain whether summary of findings table ‐ Contact immunotherapy (diphencyprone) +… changes short‐term hair regrowth ≥ 75% (between 12 and 26 weeks of compared with contact immunotherapy (diphencyprone) (very low certainty).

1 finding from 1 review