Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,615 questions · 1,673 findings · 190 reviews · Headline outcomes only

No studies found 278 · 16.6%GRADE not reported 85 · 5.1%Very low 328 · 19.6%Low 460 · 27.5%Moderate 402 · 24%High 120 · 7.2%

Intervention not reported

Risk of adverse events (until time of hospital discharge) · individuals with infant botulism

The intervention showed no clear difference in risk of adverse events (until time of hospital discharge) (moderate certainty).

1 finding from 1 review

Intervention not reported

Fractures · individuals with osteoporotic vertebral fracture

It is very uncertain whether the intervention changes fractures (very low certainty).

1 finding from 1 review

Intervention not reported

Falls · individuals with osteoporotic vertebral fracture

It is very uncertain whether the intervention changes falls (very low certainty).

1 finding from 1 review

Intervention not reported

Pain Scale: VAS (0 to 10), pain subscale of Functional Status Index (0 to 10) Higher score indicates greater pain levels · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Intervention not reported

Physical performance: self‐report questionnaires Physical function subscale from the QUALEFFO‐41 Scale from 0 to 100 Lower scores indicate better physical function · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Intervention not reported

Disease‐specific quality of life QUALEFFO‐41 total score Scale from 0 to 100 Lower scores indicate better quality of life · individuals with osteoporotic vertebral fracture
1 finding from 1 review

Interpersonal Psychotherapy for Depression (IPT‐D) vs Other Psychological Interventions

Substance use ‐ relapse · co‐occurring depression and substance use disorders

It is very uncertain whether interpersonal Psychotherapy for Depression (IPT‐D) changes substance use ‐ relapse compared with other Psychological Interventions (very low certainty).

1 finding from 1 review

Interpersonal Psychotherapy for Depression (IPT‐D) vs Other Psychological Interventions

Retention in treatment · co‐occurring depression and substance use disorders

It is very uncertain whether interpersonal Psychotherapy for Depression (IPT‐D) changes treatment retention compared with other Psychological Interventions (very low certainty).

1 finding from 1 review

Interpersonal Psychotherapy for Depression (IPT‐D) vs Other Psychological Interventions

Depression score · co‐occurring depression and substance use disorders
2 findings from 1 review

Intervention not reported

Global quality of life FLIC total score (Blanchard 1996), FACT‐G total score (Northouse 2007). Additional studies (reported in comments section): FACT‐B physical functioning subscale (Baucom 2009). EPIC multiple subscales and overall scores (Campb... · individuals with cancer (patients)
1 finding from 1 review

Intervention not reported

Global quality of life FLIC total score (Blanchard 1996), EORTC‐QLQ‐C30 global health status score (Ledderer 2013), FACT‐G total score (Northouse 2007). Additional study (reported in comments section): FACT‐B physical functioning subscale (Baucom ... · individuals with cancer (patients)
1 finding from 1 review

Corticosteroids vs no corticosteroid use

All‐cause mortality Up to 28 days following admission · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number of deaths at 30 days following admission (30‐day mortality)a compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review

Corticosteroids vs no corticosteroid use

Number and nature of adverse events secondary to corticosteroid use (hospital‐acquired infection) · individuals with influenza

It is very uncertain whether corticosteroid therapy changes number and nature of adverse events secondary to corticosteroid use… compared with no corticosteroid therapy (very low certainty).

1 finding from 1 review