Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,097 questions · 1,119 findings · 70 reviews · Kidney and Transplant

No studies found 271 · 24.2%GRADE not reported 17 · 1.5%Very low 271 · 24.2%Low 349 · 31.2%Moderate 182 · 16.3%High 29 · 2.6%

Antibiotic 1 vs antibiotic 2

Recurrence of symptomatic UTI: cotrimoxazole (1) versus cefprozil (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in recurrence of symptomatic UTI: cotrimoxazole (1) versus cefprozil (2) compared with antibiotic 2 (moderate certainty).

2 findings from 1 review

Antibiotic 1 vs antibiotic 2

Microbial resistance to prophylactic drugs: nitrofurantoin (1) versus cotrimoxazole (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 probably leads to lower microbial resistance to prophylactic drugs: nitrofurantoin (1)… compared with antibiotic 2 (moderate certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: cotrimoxazole (1) versus cefprozil (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in adverse events: cotrimoxazole (1) versus cefprozil (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Adverse events: nitrofurantoin (1) versus trimethoprim (2) · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 may leads to higher adverse events: nitrofurantoin (1) versus trimethoprim (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review

Antibiotic 1 vs antibiotic 2

Recurrence of symptomatic UTI in children · children with primarily normal renal tracts who have experienced at least one UTI

Antibiotic 1 showed no clear difference in recurrence of symptomatic UTI: cotrimoxazole (1) versus cefadroxil (2) compared with antibiotic 2 (low certainty).

1 finding from 1 review