What do systematic reviews say?

Summary of findings: Specialist inpatient care for weight restoration vs active outpatient or combination brief hospital/outpatient care

It is very uncertain whether summary of findings: Specialist inpatient care for weight restoration changes acceptability: number of participants who completed treatment (at… compared with active outpatient or combination brief hospital/outpatient care (very low certainty).

• Inpatient versus outpatient care, partial hospitalisation and waiting list for people with eating disorders 2019 · Cochrane Headline outcomes only
  RR 0.75 [0.64, 0.88]
  3 studies · 319 participants
  Very low

Ultrasound guidance vs no ultrasound

Ultrasound guidance showed no clear difference in failed blocks compared with no ultrasound guidance (moderate certainty).

• The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  22 studies · 1789 participants
  Moderate

Ultrasound guidance vs no ultrasound

• The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  15 studies · 982 participants
  Moderate

Ultrasound guidance vs no ultrasound

• The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 460 participants
  High

Ultrasound guidance vs no ultrasound

• The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  9 studies · 680 participants
  Moderate

Ultrasound guidance vs no ultrasound

• The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 256 participants
  Very low

Ultrasound guidance vs no ultrasound

Ultrasound guidance showed no clear difference in minor complications compared with no ultrasound guidance (low certainty).

• The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
  no estimate extracted
  13 studies · 896 participants
  Low

Ultrasound guidance vs no ultrasound

Ultrasound guidance showed no clear difference in major complications compared with no ultrasound guidance (moderate certainty).

• The use of ultrasound guidance for perioperative neuraxial and peripheral nerve blocks in children 2019 · Cochrane Headline outcomes only
  RD 0
  22 studies · 1576 participants
  Moderate

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

• Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 509 participants
  Moderate

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

Group 1 Pulmonary arterial hypertension ‐ PDE5i showed no clear difference in mortality compared with placebo, on combination therapy (moderate certainty).

• Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
  OR 0.26 [0.07, 1.06]
  3 studies · 492 participants
  Moderate

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

• Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 267 participants
  Moderate

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

• Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 387 participants
  High

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

• Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 310 participants
  High

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

• Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 303 participants
  High

Group 1 Pulmonary arterial hypertension ‐ PDE5i vs placebo, on combination therapy

Group 1 Pulmonary arterial hypertension ‐ PDE5i showed no clear difference in improvement in WHO functional class compared with placebo, on combination therapy (moderate certainty).

• Phosphodiesterase 5 inhibitors for pulmonary hypertension 2019 · Cochrane Headline outcomes only
  OR 1.2 [0.66, 2.17]
  2 studies · 227 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Summary of findings ‐ Intravenous lorazepam showed no clear difference in seizure cessation: within 10 minutes compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 1 [0.98, 1.02]
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Summary of findings ‐ Intravenous lorazepam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.78 [0.22, 2.82]
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

Summary of findings ‐ Intravenous lorazepam showed no clear difference in additional drugs required to stop the seizure compared with intravenous diazepam/intravenous phenytoin combination (moderate certainty).

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  RR 0.42 [0.17, 1.04]
  1 study · 178 participants
  Moderate

Summary of findings ‐ Intravenous lorazepam vs intravenous diazepam/intravenous phenytoin combination

• Drug management for acute tonic‐clonic convulsions including convulsive status epilepticus in children 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 178 participants
  Moderate