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Search review questions

Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

Population

Intervention or exposure

Comparison

Outcome

Any field or review title

Field or topic

Source

Review versions

2,112 questions in 171 reviews · Eyes and Vision

current versions

No studies 587 · 27.8%Ungraded 95 · 4.5%Very low 446 · 21.1%Low 557 · 26.4%Moderate 361 · 17.1%High 66 · 3.1%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Intervention NR Adverse events: retinal detachment during · patients with choroidal neovascularisation secondary to age‐related macular degeneration Submacular surgery for choroidal neovascularisation secondary to age‐related macular degeneration (2009) · Cochrane	RR 6.13 [2.81, 13.38]	2 studies · 790 participants	High
Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose Loss of 3 or more lines (15 or more letters) visual acuity ETDRS chart · patients with neovascular age‐related macular degeneration Photodynamic therapy for neovascular age‐related macular degeneration (2007) · Cochrane	RR 0.8 [0.73, 0.88]	4 studies · 1381 participants	High
Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose Loss of 6 or more lines (30 or more letters) visual acuity ETDRS chart · patients with neovascular age‐related macular degeneration Photodynamic therapy for neovascular age‐related macular degeneration (2007) · Cochrane	RR 0.66 [0.53, 0.83]	4 studies · 1381 participants	High
Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose Gain of 3 or more lines (15 or more letters) · patients with neovascular age‐related macular degeneration Photodynamic therapy for neovascular age‐related macular degeneration (2007) · Cochrane	RR 2.23 [1.19, 4.19]	3 studies · 941 participants	High
Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose Adverse effects: acute severe visual acuity decrease · patients with neovascular age‐related macular degeneration Photodynamic therapy for neovascular age‐related macular degeneration (2007) · Cochrane	RR 3.75 [0.87, 16.12]	3 studies · 1075 participants	Moderate
Photodynamic therapy with verteporfin vs photodynamic therapy with 5% dextrose Adverse effects: infusion‐related back pain · patients with neovascular age‐related macular degeneration Photodynamic therapy for neovascular age‐related macular degeneration (2007) · Cochrane	RR 9.93 [2.82, 35.02]	4 studies · 1439 participants	High
Intervention NR Trabeculectomy failure at 12 months · People undergoing trabeculectomy surgery with glaucoma Intraoperative Mitomycin C for glaucoma surgery (2005) · Cochrane	RR 0.37 [0.26, 0.51]	11 studies · 698 participants	Moderate
Intervention NR mean intraocular pressure mmHg at 12 months · People undergoing trabeculectomy surgery with glaucoma Intraoperative Mitomycin C for glaucoma surgery (2005) · Cochrane	no estimate extracted	380 participants	Moderate
Intervention NR complications wound leak by 12 months · People undergoing trabeculectomy surgery with glaucoma Intraoperative Mitomycin C for glaucoma surgery (2005) · Cochrane	RR 1.84 [0.72, 4.66]	7 studies · 333 participants	Low
Intervention NR complications hypotony occurring up to 12 months · People undergoing trabeculectomy surgery with glaucoma Intraoperative Mitomycin C for glaucoma surgery (2005) · Cochrane	RR 1.8 [0.79, 4.12]	10 studies · 488 participants	Low
Intervention NR complications shallow anterior chamber occurring within 12 months · People undergoing trabeculectomy surgery with glaucoma Intraoperative Mitomycin C for glaucoma surgery (2005) · Cochrane	RR 1.14 [0.42, 3.07]	10 studies · 441 participants	Low
Intervention NR cataract formation by 12 months · People undergoing trabeculectomy surgery with glaucoma Intraoperative Mitomycin C for glaucoma surgery (2005) · Cochrane	RR 1.8 [1, 3.22]	7 studies · 482 participants	Moderate