Findings

What do systematic reviews say?

4,678 questions · 4,859 findings · 283 reviews

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No studies found 1,225 · 25.2%GRADE not reported 215 · 4.4%Very low 1,241 · 25.5%Low 1,210 · 24.9%Moderate 776 · 16%High 192 · 4%

Summary of findings: punctal plugs vs cyclosporine A

Ocular surface staining · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings: punctal plugs vs cyclosporine A

Aqueous tear production · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Summary of findings: urate oxidase vs allopurinol

Incidence of clinical tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase showed no clear difference in incidence of clinical tumour lysis syndrome ( compared with allopurinol (low certainty).

1 finding from 1 review

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 2017 · Cochrane Headline outcomes only
RR 0.77 [0.44, 1.33]
1 study · 348 participants
Low

Summary of findings: urate oxidase vs allopurinol

Mortality due to tumour lysis syndrome · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase may leads to lower mortality due to tumour lysis syndrome ( compared with allopurinol (low certainty).

1 finding from 1 review

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 2017 · Cochrane Headline outcomes only
RR 0.05 [0, 0.89]
3 studies · 396 participants
Low

Summary of findings: urate oxidase vs allopurinol

Organ system failure ‐ Renal insufficiency leading to replacement therapy · children with haematological malignancy at risk of tumour lysis syndrome

It is very uncertain whether summary of findings: urate oxidase changes renal failure requiring renal replacement therapy ( compared with allopurinol (very low certainty).

1 finding from 1 review

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 2017 · Cochrane Headline outcomes only
RR 0.26 [0.08, 0.89]
5 studies · 992 participants
Very low

Summary of findings: urate oxidase vs allopurinol

Serum urate normalisation ‐ not reported · children with haematological malignancy at risk of tumour lysis syndrome

1 finding from 1 review

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 19 participants
Low

Summary of findings: urate oxidase vs allopurinol

Percentage reduction in serum uric acid level · children with haematological malignancy at risk of tumour lysis syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: urate oxidase vs allopurinol

AUC of serum uric acid level · children with haematological malignancy at risk of tumour lysis syndrome

1 finding from 1 review

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 52 participants
Low

Summary of findings: urate oxidase vs allopurinol

Frequency of adverse events ( · children with haematological malignancy at risk of tumour lysis syndrome

Summary of findings: urate oxidase may leads to higher frequency of adverse events ( compared with allopurinol (low certainty).

1 finding from 1 review

Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer 2017 · Cochrane Headline outcomes only
RR 9.1 [1.29, 64]
3 studies · 345 participants
Low

Summary of findings: Non‐intensive vs intensive follow‐up

Overall survival · women treated for early breast cancer

Summary of findings: Non‐intensive showed no clear difference in overall survival compared with intensive follow‐up (high certainty).

1 finding from 1 review

Follow‐up strategies for women treated for early breast cancer 2016 · Cochrane Headline outcomes only
HR 0.98 [0.84, 1.15]
2 studies · 2563 participants
High

Summary of findings: Non‐intensive vs intensive follow‐up

Disease-free survival · women treated for early breast cancer

Summary of findings: Non‐intensive showed no clear difference in disease‐free survival compared with intensive follow‐up (low certainty).

1 finding from 1 review

Follow‐up strategies for women treated for early breast cancer 2016 · Cochrane Headline outcomes only
HR 0.84 [0.71, 1]
2 studies · 2563 participants
Low

Summary of findings: Non‐intensive vs intensive follow‐up

Quality of life4 · women treated for early breast cancer

1 finding from 1 review

Follow‐up strategies for women treated for early breast cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 639 participants
High

Summary of findings: Decentralised vs centralised follow‐up

Overall survival · women treated for early breast cancer

Summary of findings: Decentralised showed no clear difference in overall survival compared with centralised follow‐up (moderate certainty).

1 finding from 1 review

Follow‐up strategies for women treated for early breast cancer 2016 · Cochrane Headline outcomes only
HR 1.07 [0.64, 1.78]
1 study · 968 participants
Moderate

Summary of findings: Decentralised vs centralised follow‐up

Disease-free survival · women treated for early breast cancer

Summary of findings: Decentralised showed no clear difference in disease‐free survival compared with centralised follow‐up (moderate certainty).

1 finding from 1 review

Follow‐up strategies for women treated for early breast cancer 2016 · Cochrane Headline outcomes only
HR 1.06 [0.76, 1.47]
2 studies · 1264 participants
Moderate

Summary of findings: Decentralised vs centralised follow‐up

Quality of life5 · women treated for early breast cancer

1 finding from 1 review

Follow‐up strategies for women treated for early breast cancer 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 356 participants
High

Summary of findings ‐ Hydrotherapy vs no exercise

Adverse events · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Hydrotherapy vs no exercise

Quality of life · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Hydrotherapy vs no exercise

Pain · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Hydrotherapy vs no exercise

Functional ability · participants with haemophilia

The review found no eligible studies for this question.

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings ‐ Hydrotherapy vs no exercise

Range of Motion: flexion and extension · participants with haemophilia

1 finding from 1 review

Exercise for haemophilia 2016 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low