Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,938 questions · 1,994 findings · 246 reviews · Headline outcomes only

No studies found 490 · 24.6%GRADE not reported 71 · 3.6%Very low 669 · 33.6%Low 446 · 22.4%Moderate 264 · 13.2%High 54 · 2.7%

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Overall survival · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher overall survival compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Clinical progression · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher clinical progression compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Treatment failure · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher treatment failure compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Breast pain · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher breast pain compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Gynaecomastia · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to higher gynaecomastia compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review

Non‐steroidal antiandrogen monotherapy vs LHRH agonists or surgical castration monotherapy

Hot flashes · men with advanced prostate cancer

Non‐steroidal antiandrogen monotherapy probably leads to lower hot flashes compared with LHRH agonists or surgical castration monotherapy (moderate certainty).

1 finding from 1 review