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Evidence found and GRADE certainty

1,368 questions · 1,413 findings · 89 reviews · Common Mental Disorders

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No studies found 232 · 16.4%GRADE not reported 82 · 5.8%Very low 395 · 28%Low 331 · 23.4%Moderate 341 · 24.1%High 32 · 2.3%

Active music therapy vs receptive music therapy

Behaviour: Leaving the study early (short‐term) · depression in adults

It is very uncertain whether active music therapy changes leaving the study early Up to 3 months compared with receptive music therapy (very low certainty).

1 finding from 1 review

Music therapy plus treatment as usual (TAU) vs TAU

Any adverse events Up to 3 months · patients with depression

Music therapy plus treatment as usual (TAU) showed no clear difference in any adverse events Up to 3 months compared with TAU (low certainty).

1 finding from 1 review

Music therapy plus treatment as usual (TAU) vs TAU

Behaviour: Leaving the study early (short‐term) · patients with depression

Music therapy plus treatment as usual (TAU) showed no clear difference in leaving the study early Up to 3 months compared with TAU (moderate certainty).

1 finding from 1 review

Vortioxetine vs placebo

Response · adults with Major Depressive Disorder

Vortioxetine may leads to higher response compared with placebo (low certainty).

1 finding from 1 review

Vortioxetine vs SNRIs

Remission · adults with Major Depressive Disorder

It is very uncertain whether vortioxetine changes remission compared with SNRIs (very low certainty).

1 finding from 1 review

Vortioxetine vs SNRIs

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

It is very uncertain whether vortioxetine changes drop‐out due to adverse events compared with SNRIs (very low certainty).

1 finding from 1 review

Vortioxetine vs SNRIs

Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants · adults with Major Depressive Disorder

It is very uncertain whether vortioxetine changes drop‐out due to inefficacy compared with SNRIs (very low certainty).

1 finding from 1 review

Vortioxetine vs SNRIs

Tolerability · adults with Major Depressive Disorder

Vortioxetine may leads to lower tolerability compared with SNRIs (low certainty).

1 finding from 1 review

Vortioxetine vs placebo

Total number of drop‐outs · adults with Major Depressive Disorder

Vortioxetine showed no clear difference in total number of drop‐outs compared with placebo (moderate certainty).

1 finding from 1 review

Vortioxetine vs placebo

Remission · adults with Major Depressive Disorder

Vortioxetine may leads to higher remission compared with placebo (low certainty).

1 finding from 1 review

Vortioxetine vs placebo

Adverse effects (drop‐outs due to adverse effects4) · adults with Major Depressive Disorder

Vortioxetine probably leads to higher drop‐out due to adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Vortioxetine vs placebo

Drop out due to inefficacy Number of participants who dropped out due to inefficacy during the trial, as a proportion of the total number of randomised participants · adults with Major Depressive Disorder

Vortioxetine probably leads to lower drop‐out due to inefficacy compared with placebo (moderate certainty).

1 finding from 1 review

Vortioxetine vs placebo

Tolerability · adults with Major Depressive Disorder

Vortioxetine probably leads to higher tolerability compared with placebo (moderate certainty).

1 finding from 1 review