Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Bronchopulmonary dysplasia · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in bronchopulmonary dysplasia№ of participants: 562(3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Bronchopulmonary dysplasia or mortality ‐ not reported · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Surfactant utilization № of participants: 562 (3 RCTs) · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in surfactant utilization № of participants: 562 (3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Pneumothorax · preterm infants at risk of respiratory distress syndrome

Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in any pneumothorax№ of participants: 506(2 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).

1 finding from 1 review

Surfactant treatment guided by rapid tests for surfactant deficiency vs surfactant therapy provided to preterm infants with respiratory distress syndrome diagnosed on clinical and radiologic criteria

Neurodevelopmental outcomes · preterm infants at risk of respiratory distress syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (Children < 5a) · adults and children

The intervention probably leads to lower diarrhoea prevalence (Children < 5a) (moderate certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (All ages) · adults and children

The intervention may leads to lower diarrhoea prevalence (All ages) (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (Children < 5) · adults and children

The intervention may leads to lower diarrhoea prevalence (Children < 5) (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (All ages) · adults and children

The intervention showed no clear difference in diarrhoea prevalence (All ages) (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (Children < 5) · adults and children

The intervention showed no clear difference in diarrhoea prevalence (Children < 5) (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (Children < 5a) · adults and children

The intervention showed no clear difference in diarrhoea prevalence (Children < 5a) (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (All ages) · adults and children

The intervention may leads to lower diarrhoea prevalence (All ages) (low certainty).

1 finding from 1 review

Intervention not reported

Diarrhoea prevalence (Children < 5) · adults and children

It is very uncertain whether the intervention changes diarrhoea prevalence (Children < 5) (very low certainty).

1 finding from 1 review

Intervention not reported

PTSD in the relatives IES (0 to 75; > 30 = presence of PTSD) measured at 3 months and > 3 months · relatives, patients, and healthcare professionals during resucitation
1 finding from 1 review

Intervention not reported

Anxiety and depression in the relatives HADS (0 to 42; subscale score > 10 (range, 0 to 21) = presence of anxiety or depression) measured at 3 months and > 3 months · relatives, patients, and healthcare professionals during resucitation
1 finding from 1 review

Intervention not reported

Grief in the relatives ICG (0 to 95; > 25 = presence of complicated grief) measured at 12 months TRIG (21 to 105; lower scores indicate higher levels of grief) measured at 3 and 9 months · relatives, patients, and healthcare professionals during resucitation
1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Live birth or ongoing pregnancy · assisted reproduction technology cycles
3 findings from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Live birth or ongoing pregnancy sensitivity analysis ‐ PCOS (high‐responders) ‐ own oocytes ‐ early phase stimulation protocol ‐ frozen embryo transfer (micronised progesterone 100 mg/day versus GnRH antagonists) · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in live birth or ongoing pregnancy sensitivity analysis ‐ PCOS… compared with gnRH antagonists; GRADE not reported.

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Clinical pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in clinical pregnancy ‐ Poor‐responders (MPA 10 mg versus GnRH… compared with gnRH antagonists (low certainty).

1 finding from 1 review