What do systematic reviews say?

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with no bowel preparation (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.2 [0.01, 4.22]
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in incidence of postoperative ileus compared with no bowel preparation (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 1.18 [0.77, 1.81]
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs no bowel preparation

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 396 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Summary of findings table ‐ Combined mechanical and oral antibiotic… probably leads to lower anastomotic leakage compared with mechanical bowel preparation alone (moderate certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.6 [0.36, 0.99]
  10 studies · 2356 participants
  Moderate

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in mortality compared with mechanical bowel preparation alone (moderate certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.87 [0.27, 2.82]
  3 studies · 639 participants
  Moderate

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

Summary of findings table ‐ Combined mechanical and oral antibiotic… showed no clear difference in incidence of postoperative ileus compared with mechanical bowel preparation alone (low certainty).

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  RR 0.89 [0.59, 1.32]
  6 studies · 2013 participants
  Low

Summary of findings table ‐ Combined mechanical and oral antibiotic bowel preparation vs mechanical bowel preparation alone

• Preoperative combined mechanical and oral antibiotic bowel preparation for preventing complications in elective… 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 621 participants
  Moderate

Triple antibiotic paste (TAP) vs Abscess remedy (AR)

A single RCT found higher pulpotomy success with triple antibiotic paste than abscess remedy (100% vs 80%; statistically significant, P<0.05; not pooled; ungraded).

• Materials for pulpotomy in immature permanent teeth: a systematic review and meta-analysis. 2019 All outcomes

  3 to 24 months · Pediatric dental clinic (India)
  Single RCT (Eppa 2018, 3-arm; 20 TAP and 20 AR teeth): TAP 100% (20/20) vs abscess remedy 80% (16/20) clinical and radiographic success; difference statistically significant at 3, 6, 9, 12, 18 and 24 months (P<0.05);…
  1 study · 40 participants
  GRADE not reported

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower dry socket compared with placebo (low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 7th day
  RR 0.66 [0.45, 0.97]
  13 studies · 1882 participants
  Low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

Systemic antibiotic prophylaxis (any regimen; topical therapy… may leads to lower postsurgical infectious complications compared with placebo (low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 14th day
  RR 0.34 [0.19, 0.64]
  12 studies · 1728 participants
  Low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes swelling (7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  7th day
  RR 0.80 [0.50, 1.27]
  4 studies · 452 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes pain (continuous, VAS 0-10 cm, 7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  MD -0.26 [-0.59, 0.07]
  4 studies · 422 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes presence of pain (dichotomous, yes/no on 6th-7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  RR 0.59 [0.31, 1.12]
  3 studies · 675 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes adverse effects compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  1st to 7th day
  RR 1.46 [0.81, 2.64]
  8 studies · 1277 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes trismus (dichotomous, 7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  7th day
  RR 0.77 [0.42, 1.41]
  3 studies · 199 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo

The review found no eligible studies for this question.

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes
  No studies: none of the 23 included trials evaluated tooth extraction in immunocompromised patients; subgroup analysis based on immune status was not possible as no such studies were identified.
  0 studies
  No studies found

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs placebo

It is very uncertain whether systemic antibiotic prophylaxis (any regimen; topical therapy… changes fever (6th-7th day) compared with placebo (very low certainty).

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes

  6th to 7th day
  RR 0.66 [0.24, 1.79]
  4 studies · 475 participants
  Very low

Systemic antibiotic prophylaxis (any regimen; topical therapy excluded) administered before and/or after tooth extraction vs Placebo

The review found no eligible studies for this question.

• Antibiotics to prevent complications following tooth extractions 2021 · Cochrane All outcomes
  No studies in general dental practice for removal of decayed teeth. PUB3 added one routine intra-alveolar extraction trial and one complex oral surgery trial (2 of 23 non-third-molar), but the single intra-alveolar…
  0 studies
  No studies found

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

The review found no eligible studies for this question.

• Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes

  24 hours
  No data available for this outcome.
  0 studies
  No studies found
• Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes

  7 days
  RR 0.50 [0.10, 2.56]
  1 study · 72 participants
  Low
• Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes

  72 hours
  No data available for this outcome.
  0 studies
  No studies found

Single preoperative dose of systemic antibiotics (clindamycin 600 mg), total chemo-mechanical debridement and root filling vs Matched placebo, total chemo-mechanical debridement and root filling

• Systemic antibiotics for symptomatic apical periodontitis and acute apical abscess in adults 2024 · Cochrane All outcomes

  24 hours
  The median pain at 24 hours in the control group was 3 (range 0 to 10); the median pain at 24 hours in the intervention group was the same (median 3, range 0 to 8). P = 0.219 (Mann-Whitney U).
  1 study · 72 participants
  Low