Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,149 questions · 1,211 findings · 179 reviews

No studies found 175 · 14.5%GRADE not reported 86 · 7.1%Very low 286 · 23.6%Low 341 · 28.2%Moderate 254 · 21%High 69 · 5.7%

Intervention not reported

Clinical global impression of change ‐ patient's self‐reported impression of memory change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ patient's self‐reported… (high certainty).

1 finding from 1 review

Intervention not reported

Clinical global impression of change ‐ patient's self‐reported impression of cognitive change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ patient's self‐reported… (high certainty).

1 finding from 1 review

Intervention not reported

Clinical global impression of change ‐ clinician's impression of memory change · Multiple sclerosis

The intervention showed no clear difference in clinical global impression of change ‐ clinician's impression of… (moderate certainty).

1 finding from 1 review

Intervention not reported

Clinical global impression of change ‐ clinician's impression of cognitive change · Multiple sclerosis

The intervention leads to higher clinical global impression of change ‐ clinician's impression of… (high certainty).

1 finding from 1 review

Intervention not reported

At least 50% reduction in pain · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

At least 30% reduction in pain · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

Proportion below 30/100 mm on VAS · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Patient Global Impression of Change very much improved (patient global evaluation of pain relief complete or good) · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

Patient Global Impression of Change much or very much improved (patient global evaluation of pain relief complete, good or moderate) · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

Any measure of 'substantial' pain relief · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

Adverse event withdrawals · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…

It is very uncertain whether the intervention changes adverse event withdrawals (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Intervention not reported

Death · neuropathic pain (6 studies in central neuropathic pain due to multiple sclerosis, spinal cord injury, polyneuropathy, central post‐stroke…
1 finding from 1 review

Ultrasonic instrumentation used alone (any ultrasonic device designed specifically for root canal treatment and capable of the active or passive removal of dentine within the root canal) vs Hand instrumentation used alone (files and reamers used manually)

Outcome not reported · People over 18 years of age with single or multiple permanent teeth with a completely formed apex and no evidence of internal resorption,…

The review found no eligible studies for this question.

1 finding from 1 review