Participants with 1 or more serious adverse events · patients with Guillain‐Barré syndrome
It is very uncertain whether interferon beta‐1a changes participants with 1 or more serious adverse events compared with placebo (very low certainty).
1 finding from 1 review
Improvement in disability grade after 4 weeks · patients with Guillain‐Barré syndrome
1 finding from 1 review
Improvement in disability grade Defined as achievement of a specified degree of improvement · patients with Guillain‐Barré syndrome
It is very uncertain whether brain‐derived neurotrophic factor changes improvement in disability grade Defined as achievement of a… compared with placebo (very low certainty).
1 finding from 1 review
Intervention not reported
Lung function Mean percentage change in FEV1 · adults and children with cystic fibrosis
1 finding from 1 review
Intervention not reported
Lung function Mean percentage change in FVC (% predicted) · adults and children with cystic fibrosis
1 finding from 1 review
Intervention not reported
Nutritional status BMI · adults and children with cystic fibrosis
1 finding from 1 review
Intervention not reported
Antibiotic resistance patterns following treatment · adults and children with cystic fibrosis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Intervention not reported
Ototoxicity An increase in auditory threshold of 20 dB or more over any frequency range · adults and children with cystic fibrosis
The intervention showed no clear difference in ototoxicity An increase in auditory threshold of 20 dB or more over… (low certainty).
1 finding from 1 review
Intervention not reported
Nephrotoxicity The percentage change in creatinine over baseline · adults and children with cystic fibrosis
1 finding from 1 review
Seizure freedom · patients with drug‐resistant epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Satisfactory seizure control 50% or greater reduction in seizure frequency for drug‐resistant epilepsy · patients with drug‐resistant epilepsy
IVIg showed no clear difference in satisfactory seizure control 50% or greater reduction in seizure… compared with placebo (low certainty).
1 finding from 1 review
All harmful effects · patients with drug‐resistant epilepsy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Global assessment · patients with drug‐resistant epilepsy
IVIg may leads to higher global assessment compared with placebo (low certainty).
1 finding from 1 review
Nausea · participants aged 6 months or older undergoing surgical procedures under general anaesthesia
Supplemental IV crystalloid probably leads to lower risk of PON, defined as the presence of subjective nausea, reported… compared with control IV crystalloid volume (moderate certainty).
1 finding from 1 review
Risk of POV, reported dichotomously by any discrete episodes of vomiting · participants aged 6 months or older undergoing surgical procedures under general anaesthesia
Supplemental IV crystalloid probably leads to lower risk of POV, reported dichotomously by any discrete episodes of… compared with control IV crystalloid volume (moderate certainty).
1 finding from 1 review
Risk of requiring pharmacologic treatment for PONV, reported dichotomously as the use of any medication intended to treat nausea or vomiting during the postoperative period · participants aged 6 months or older undergoing surgical procedures under general anaesthesia
Supplemental IV crystalloid probably leads to lower risk of requiring pharmacologic treatment for PONV, reported… compared with control IV crystalloid volume (moderate certainty).
1 finding from 1 review
Risk of unintended postoperative admission to hospital, reported dichotomously as admission to an inpatient unit of a participant after an intended ambulatory surgical procedure · participants aged 6 months or older undergoing surgical procedures under general anaesthesia
Supplemental IV crystalloid showed no clear difference in risk of unintended postoperative admission to hospital, reported… compared with control IV crystalloid volume (low certainty).
1 finding from 1 review
Risk of suffering a serious adverse event, reported dichotomously as the occurrence of any of: admission to high‐dependency unit, postoperative cardiac or respiratory complication, or death · participants aged 6 months or older undergoing surgical procedures under general anaesthesia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Postoperative delirium (One study used DRS, three studies used CAM and in one study diagnostic tool was not reported) Time points were up to 4 days postoperatively
It is very uncertain whether summary of findings TIVA changes postoperative delirium (One study used DRS, three studies used CAM… compared with inhalational maintenance of anaesthesia (very low certainty).
1 finding from 1 review
Postoperative cognitive dysfunction (9 studies used MMSE, and 2 of these studies used additional diagnostic tools; 1 study used Trail Making Test and additional diagnostic tools; 3 studies did not report diagnostic tools) Time points were up to 30...
Summary of findings TIVA may leads to lower postoperative cognitive dysfunction (9 studies used MMSE, and 2 of… compared with inhalational maintenance of anaesthesia (low certainty).
1 finding from 1 review