Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,888 questions · 2,009 findings · 352 reviews

No studies found 224 · 11.1%GRADE not reported 265 · 13.2%Very low 551 · 27.4%Low 540 · 26.9%Moderate 311 · 15.5%High 118 · 5.9%

Educational intervention with information and practical components (theoretical oral health education plus practical skills training) for nursing staff and/or residents vs usual care

Leaving the study early · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Oral health education (advice and training) showed no clear difference in leaving the study early compared with standard care (oral health advice not specifically emphasised beyond… (moderate certainty).

1 finding from 1 review

Motivational interview plus oral health education vs Oral health education

Leaving the study early · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Motivational interview plus oral health education showed no clear difference in leaving the study early compared with oral health education (moderate certainty).

1 finding from 1 review

Monitoring (any means of observation, supervision, keeping under review, measuring or testing at intervals) vs No monitoring

Leaving the study early · People with serious mental illness (all included participants had schizophrenia); majority aged 18 to 65 years per NIMH 1987, or with…

Monitoring (any means of observation, supervision, keeping under… showed no clear difference in leaving the study early compared with no monitoring (moderate certainty).

1 finding from 1 review

Intervention not reported

Early mortality (90 days) · patients with diffuse emphysema

The intervention probably leads to higher early mortality (90 days) (moderate certainty).

1 finding from 1 review

Non‐healthcare professional‐led breastfeeding education and support vs usual care

Early initiation of breastfeeding · women exposed to interventions intended to promote breastfeeding

It is very uncertain whether non‐healthcare professional‐led breastfeeding education and support changes early initiation of breastfeeding compared with standard care (very low certainty).

1 finding from 1 review

Intervention not reported

Miscarriage rate ‐ Early versus late clomiphene citrate · ovulation induction in polycystic ovarian syndrome

It is very uncertain whether the intervention changes miscarriage rate ‐ Early versus late clomiphene citrate (very low certainty).

1 finding from 1 review

Intervention not reported

Clinical pregnancy ‐ Early versus late clomiphene citrate · ovulation induction in polycystic ovarian syndrome

The intervention may leads to higher clinical pregnancy ‐ Early versus late clomiphene citrate (low certainty).

1 finding from 1 review

VALPROATE + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Acceptability of treatment ‐ leaving the study early · patients with schizophrenia

It is very uncertain whether VALPROATE + ANTIPSYCHOTICS changes leaving the study early: Acceptability of treatment Leaving the… compared with ANTIPSYCHOTICS + PLACEBO or ANTIPSYCHOTICS alone (very low certainty).

1 finding from 1 review

VALPROATE + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

Adverse effects – leaving the study early due to adverse effects – overall tolerability – total · patients with schizophrenia

VALPROATE + ANTIPSYCHOTICS showed no clear difference in leaving the study early: Overall tolerability Leaving the study… compared with ANTIPSYCHOTICS + PLACEBO or ANTIPSYCHOTICS alone (low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs RISPERIDONE

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

RISPERIDONE DEPOT showed no clear difference in leaving the study early: Any reason ‐ short term compared with ORAL RISPERIDONE (moderate certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs QUETIAPINE

Leaving the study early · patients with schizophrenia

RISPERIDONE DEPOT probably leads to lower leaving the study early: Any reason ‐ long term compared with ORAL QUETIAPINE (moderate certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs ARIPIPRAZOLE

Leaving the study early · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes leaving the study early: Any reason ‐ long term compared with ORAL ARIPIPRAZOLE (very low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs placebo

Leaving the study early · patients with schizophrenia

It is very uncertain whether RISPERIDONE DEPOT changes leaving the study early: Any reason ‐ all doses risperidone depot ‐… compared with PLACEBO (very low certainty).

1 finding from 1 review

RISPERIDONE DEPOT vs OLANZAPINE

Leaving the study early · patients with schizophrenia

RISPERIDONE DEPOT may leads to higher leaving the study early: Any reason ‐ long term compared with ORAL OLANZAPINE (low certainty).

1 finding from 1 review