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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.

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Intervention or exposure

Comparison

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Review versions

1,956 questions in 143 reviews · Musculoskeletal

current versions

No studies 555 · 28.4%Ungraded 107 · 5.5%Very low 255 · 13%Low 555 · 28.4%Moderate 357 · 18.3%High 127 · 6.5%

Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.

Question	Effect	Evidence	Status / GRADE
Summary of findings: leflunomide vs placebo, 6 months Pain change (0‐100 mm VAS) · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane	no estimate extracted	3 studies · 724 participants	High
Summary of findings: leflunomide vs placebo, 6 months Radiographic change (Change in Sharp score) · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane	RR 1.23 [0.91, 1.66]	1 study · 380 participants	High
Summary of findings: leflunomide vs placebo, 6 months Withdrawals due to adverse events · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane	no estimate extracted	3 studies · 727 participants	High
Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months For outcome · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane	no estimate extracted	NR	No studies
Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months ACR 50 at 6 months · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane	RR 4.35 [2.09, 9.03]	1 study · 263 participants	High
Summary of findings: leflunomide + methotrexate vs methotrexate, 6 months HAQ change Range of HAQ: 0‐3 scale (6 months) · adult patients with rheumatoid arthritis Leflunomide for the treatment of rheumatoid arthritis (2002) · Cochrane	no estimate extracted	1 study · 263 participants	High