Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Risk of postoperative infectious complications: anti‐TNF agents vs control

Intra‐abdominal infectious complications within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐TNF agents changes intra‐abdominal infectious complications within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Risk of postoperative infectious complications: anti‐TNF agents vs control

Extra‐abdominal infections within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐TNF agents changes extra‐abdominal infections within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Risk of postoperative infectious complications: anti‐integrin agents vs control

Infectious complications · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐integrin agents changes overall infectious complications within 30 days of surgery compared with control (very low certainty).

3 findings from 1 review

Risk of postoperative infectious complications: anti‐integrin agents vs control

Incisional infections and wound dehiscence within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐integrin agents changes incisional infections and wound dehiscence within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Risk of postoperative infectious complications: anti‐integrin agents vs control

Intra‐abdominal infectious complications within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐integrin agents changes intra‐abdominal infectious complications within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Risk of postoperative infectious complications: anti‐integrin agents vs control

Extra‐abdominal infections within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: anti‐integrin agents changes extra‐abdominal infections within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Incisional infections and wound dehiscence within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes incisional infections and wound dehiscence within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Intra‐abdominal infectious complications within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes intra‐abdominal infectious complications within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

Corticosteroids vs control

Extra‐abdominal infections within 30 days of surgery · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: corticosteroids changes extra‐abdominal infections within 30 days of surgery compared with control (very low certainty).

1 finding from 1 review

5‐ASA vs control

Infectious complications · people with inflammatory bowel disease

It is very uncertain whether risk of postoperative infectious complications: 5‐ASA changes overall infectious complications within 30 days of surgery compared with control (very low certainty).

3 findings from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Mastectomy skin flap necrosis (number of women with mastectomy skin flap necrosis within 30 days after surgery) · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes mastectomy skin flap necrosis (number of women with mastectomy skin… compared with clinical evaluation (very low certainty).

1 finding from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Infection (number of breasts with infection within 30 days after surgery) · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes infection (number of breasts with infection within 30 days after… compared with clinical evaluation (very low certainty).

1 finding from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Haematoma (number of breasts with haematoma within 30 days after surgery) · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes haematoma (number of breasts with haematoma within 30 days after… compared with clinical evaluation (very low certainty).

1 finding from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Seroma (30 days) · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes seroma (number of breast with seroma within 30 days after surgery) compared with clinical evaluation (very low certainty).

2 findings from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Reoperation · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes reoperation (number of women that were operated again within 30 days… compared with clinical evaluation (very low certainty).

2 findings from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Dehiscence · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes dehiscence (number of women with dehiscence within 30 days after… compared with clinical evaluation (very low certainty).

1 finding from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Infection (number of women with infection of the skin flap or implant within 30 days after surgery) · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes infection (number of women with infection of the skin flap or… compared with clinical evaluation (very low certainty).

1 finding from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Haematoma (proportion of participants in each group with haematoma; · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes haematoma (number of women with haematoma within 30 days after… compared with clinical evaluation (very low certainty).

1 finding from 1 review

Indocyanine Green Angiography (ICGA) vs clinical evaluation

Mastectomy skin flap necrosis (number of breasts with mastectomy skin flap necrosis within 30 days after surgery) · women undergoing immediate breast reconstruction following mastectomy

It is very uncertain whether indocyanine Green Angiography (ICGA) changes mastectomy skin flap necrosis (number of breasts with mastectomy… compared with clinical evaluation (very low certainty).

1 finding from 1 review

Retzius‐sparing RALP vs standard RALP

Urinary continence 3 months after surgery MCID: 5% absolute difference · men (ages > 18 years) with clinically localized prostate cancer

Retzius‐sparing RALP may leads to higher urinary continence 3 months after surgery MCID: 5% absolute difference compared with standard RALP (low certainty).

1 finding from 1 review