Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,106 questions · 1,152 findings · 69 reviews

No studies found 216 · 18.8%GRADE not reported 448 · 38.9%Very low 122 · 10.6%Low 195 · 16.9%Moderate 127 · 11%High 44 · 3.8%

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Mucositis eradicated · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in mucositis eradicated compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Gelclair vs Sucralfate and mucaine

Mucositis severity (mild to moderate) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Gelclair showed no clear difference in mucositis severity (mild to moderate) compared with sucralfate and mucaine; GRADE not reported.

1 finding from 1 review

Absorbed drug (fluconazole or ketoconazole) vs Antifungal drugs not absorbed from GI tract

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Absorbed drug (fluconazole or ketoconazole) led to higher mycological: eradication of oral candidiasis compared with drug not absorbed from GI tract (amphotericin B or nystatin); GRADE not reported.

1 finding from 1 review

Absorbed drug (fluconazole or ketoconazole) vs Antifungal drugs not absorbed from GI tract

Clinical: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Absorbed drug (fluconazole or ketoconazole) led to higher clinical: eradication of oral candidiasis compared with drug not absorbed from GI tract (amphotericin B or nystatin); GRADE not reported.

1 finding from 1 review

Morphine via pharmacokinetically based PCA (PKPCA) vs Morphine via patient-controlled analgesia (PCA)

Daily mean opiate intake per hour · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Morphine via pharmacokinetically based PCA (PKPCA) led to higher daily mean opiate intake per hour compared with morphine via patient-controlled analgesia (PCA); GRADE not reported.

1 finding from 1 review

Clotrimazole (partially absorbed from GI tract) vs placebo

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Clotrimazole (partially absorbed from GI tract) showed no clear difference in mycological: eradication of oral candidiasis compared with placebo; GRADE not reported.

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

Amount of analgesia · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Patient-controlled analgesia (PCA) pethidine vs Staff-controlled delivery of pethidine

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Patient-controlled analgesia (PCA) pethidine showed no clear difference in average pain scores (0-100 VAS) compared with staff-controlled delivery of pethidine; GRADE not reported.

1 finding from 1 review

Partially absorbed antifungal drug (e.g., clotrimazole, miconazole) vs Drug not absorbed from GI tract (e.g., nystatin, amphotericin B)

Outcome not reported · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Any antifungal intervention for the treatment of oral candidiasis vs Placebo, no treatment, or another active antifungal intervention

Incidence of systemic infection · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

The review found no eligible studies for this question.

1 finding from 1 review

Chlorhexidine mouthwash vs Salt and soda mouthwash

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Chlorhexidine mouthwash showed no clear difference in time to heal mucositis (days) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Ketoconazole vs placebo

Mycological: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Ketoconazole (absorbed from GI tract) showed no clear difference in mycological: eradication of oral candidiasis compared with placebo; GRADE not reported.

1 finding from 1 review

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in time to heal mucositis (days) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Clotrimazole (partially absorbed from GI tract) vs placebo

Clinical: eradication of oral candidiasis · Patients with cancer receiving chemotherapy and/or radiotherapy with overt oral candidiasis

Clotrimazole (partially absorbed from GI tract) showed no clear difference in clinical: eradication of oral candidiasis compared with placebo; GRADE not reported.

1 finding from 1 review

Therapist support (visits) vs control (e.g. usual activities)

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

Therapist support (visits) showed no clear difference in average pain scores (0-100 VAS) compared with control (treatment as usual); GRADE not reported.

1 finding from 1 review