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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
2,206 questions in 117 reviews · Common Mental Disorders
current versionsNo studies 387 · 17.5%Ungraded 111 · 5%Very low 635 · 28.8%Low 568 · 25.7%Moderate 449 · 20.4%High 56 · 2.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Antipsychotic vs placebo Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antipsychotic vs placebo Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antidepressant Clinical response · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | Very low |
Antidepressant vs antidepressant Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | Very low |
Antidepressant vs antidepressant Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antidepressant Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antidepressant Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antidepressant Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Clinical response of depression · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 2.09 [0.64, 6.82] | 1 study · 36 participants | Very low |
Antidepressant vs placebo Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.24 [0.34, 4.51] | 1 study · 27 participants | Very low |
Antidepressant vs antipsychotic Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.79 [0.18, 18.02] | 1 study · 36 participants | Very low |
Antidepressant vs antipsychotic Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs antipsychotic Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Clinical response of depression · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.86 [1.23, 2.82] | 2 studies · 148 participants | Very low |
Antidepressant plus antipsychotic vs placebo Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 0.75 [0.48, 1.18] | 2 studies · 148 participants | Very low |
Antidepressant plus antipsychotic vs placebo Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Clinical response of depression · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.83 [1.4, 2.38] | 4 studies · 447 participants | Low |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 0.79 [0.63, 1.01] | 4 studies · 447 participants | Very low |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antipsychotic Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Clinical response of depression · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.42 [1.11, 1.8] | 4 studies · 245 participants | Very low |
Antidepressant plus antipsychotic vs placebo plus antidepressant Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 0.91 [0.55, 1.5] | 4 studies · 245 participants | Very low |
Antidepressant plus antipsychotic vs placebo plus antidepressant Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus antidepressant Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Clinical response of depression · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.7 [1.19, 2.43] | 3 studies · 157 participants | Very low |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.04 [0.52, 2.07] | 3 studies · 157 participants | Very low |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Change in depression severity from baseline · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant plus antipsychotic vs placebo plus the same antidepressant Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Quality of life · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antidepressant vs placebo Dropouts due to adverse effects · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
Antipsychotic vs placebo Clinical response of depression · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 1.13 [0.74, 1.73] | 2 studies · 201 participants | Very low |
Antipsychotic vs placebo Overall dropouts · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | RR 0.79 [0.57, 1.08] | 2 studies · 201 participants | Very low |
Antipsychotic vs placebo Depression remission · adults with psychotic depression Pharmacological treatment for psychotic depression (2021) · Cochrane | no estimate extracted | NR | No studies |
n3PUFAs vs placebo Depressive symptomology (continuous)HDRS where possible; higher scores indicate greater symptomology · Adult patients with major depressive disorder (MDD) Omega‐3 fatty acids for depression in adults (2021) · Cochrane | no estimate extracted | 33 studies · 1848 participants | Very low |
n3PUFAs vs placebo Adverse eventsStudy reports · Adult patients with major depressive disorder (MDD) Omega‐3 fatty acids for depression in adults (2021) · Cochrane | OR 1.27 [0.99, 1.64] | 24 studies · 1503 participants | Very low |
n3PUFAs vs placebo Depressive symptomology (dichotomous ‐ remission)Depressive symptomology rating scale as used by authors · Adult patients with major depressive disorder (MDD) Omega‐3 fatty acids for depression in adults (2021) · Cochrane | OR 1.13 [0.74, 1.72] | 8 studies · 609 participants | Low |
n3PUFAs vs placebo Depressive symptomology (dichotomous ‐ response)Depressive symptomology rating scale as used by authors · Adult patients with major depressive disorder (MDD) Omega‐3 fatty acids for depression in adults (2021) · Cochrane | OR 1.2 [0.8, 1.79] | 17 studies · 794 participants | Low |