Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

144 questions · 147 findings · 11 reviews

No studies found 45 · 30.6%GRADE not reported 16 · 10.9%Very low 35 · 23.8%Low 27 · 18.4%Moderate 16 · 10.9%High 8 · 5.4%

Tavaborole 5% solution vs vehicle

Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Tavaborole 5% solution probably leads to higher adverse events (directly related to treatment, collected over the… compared with vehicle (moderate certainty).

1 finding from 1 review

P‐3051 (ciclopirox 8% hydrolacquer) vs comparators

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

P‐3051 (ciclopirox 8% hydrolacquer) showed no clear difference in adverse events (collected over the course of the studies; they are… compared with comparators (low certainty).

1 finding from 1 review

Nd:YAG laser vs no treatment/sham

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

It is very uncertain whether 1064‐nm Nd:YAG laser changes adverse events (collected over the course of the studies; they are… compared with no treatment or sham treatment (very low certainty).

1 finding from 1 review

Ciclopirox 8% lacquer vs vehicle

Adverse events (directly related to treatment, collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Ciclopirox 8% lacquer showed no clear difference in adverse events (directly related to treatment, collected over the… compared with vehicle (low certainty).

1 finding from 1 review

Luliconazole 5% solution vs vehicle

Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails

Luliconazole 5% solution showed no clear difference in adverse events (collected over the course of the studies; they are… compared with vehicle (low certainty).

1 finding from 1 review