Findings

What do systematic reviews say?

142 questions · 149 findings · 12 reviews · Pain, Palliative and Supportive Care

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No studies found 44 · 29.5%GRADE not reported 15 · 10.1%Very low 34 · 22.8%Low 39 · 26.2%Moderate 14 · 9.4%High 3 · 2%

Intervention not reported

Survival time from onset of inoperable MBO until death. · Adults 18 yrs and over with malignant bowel obstruction (MBO) as defined by the International Conference on MBO, with no indication for…

The review found no eligible studies for this question.

1 finding from 1 review

Oral water soluble contrast for malignant bowel obstruction 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Perioperative intravenous ketamine vs placebo

Consumption of morphine equivalents 0 to 72 hmg · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
65 studies · 4004 participants
Moderate

Perioperative intravenous ketamine vs placebo

Pain intensity VAS (0 to 100; 0 = no pain, 100 = worst pain) · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
82 studies · 5004 participants
High

Perioperative intravenous ketamine vs placebo

Analgesia durationTime duration from the end of surgery to the time of first analgesic consumption. Scale from: 0 to 100. · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
31 studies · 1678 participants
Moderate

Perioperative intravenous ketamine vs placebo

Hyperalgesia(cm2) · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
7 studies · 333 participants
Very low

Perioperative intravenous ketamine vs placebo

CNS adverse events · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
105 studies · 6538 participants
High

Perioperative intravenous ketamine vs placebo

Number of patients with postoperative nausea and vomiting (postoperative care unit) · adults undergoing surgery

1 finding from 1 review

Perioperative intravenous ketamine for acute postoperative pain in adults 2018 · Cochrane Headline outcomes only
no estimate extracted
95 studies · 5965 participants
High

Summary of findings: liposomal bupivacaine vs placebo

Cumulative pain score from the end of operation (0 hours) to 72 hours (NRS 0 to 10) · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 189 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Time to first postoperative opioid dose over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

The review found no eligible studies for this question.

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: liposomal bupivacaine vs bupivacaine

Total postoperative opioid consumption over first 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 134 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Percentage of participants not requiring postoperative opioids over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 134 participants
Very low

Summary of findings: liposomal bupivacaine vs placebo

Serious adverse events · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Low

Summary of findings: liposomal bupivacaine vs placebo

Time to first postoperative opioid dose over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Low

Summary of findings: liposomal bupivacaine vs placebo

Total postoperative opioid consumption over first 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 189 participants
Very low

Summary of findings: liposomal bupivacaine vs placebo

Percentage of participants not requiring postoperative opioids over initial 72 hours · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 382 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Cumulative pain score from the end of operation (0 hours) to 72 hours (NRS 0 to 10) · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 379 participants
Very low

Summary of findings: liposomal bupivacaine vs bupivacaine

Serious adverse events · aged 18 years and older undergoing elective surgery at any surgical site

1 finding from 1 review

Liposomal bupivacaine infiltration at the surgical site for the management of postoperative pain 2017 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 583 participants
Moderate

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Duration of postoperative analgesia · Children up to 13 years of age, undergoing cleft lip repair surgery

The review found no eligible studies for this question.

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
This outcome was not reported.
0 studies
No studies found

Perioperative infraorbital nerve block vs Intravenous analgesia

Adverse events · Children up to 13 years of age, undergoing cleft lip repair surgery

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
2 out of 3 studies reported this outcome. Both studies reported no difference between groups (Rajamani 2007 and Simion 2008: no adverse events attributable to either technique; Delgado 2005 did not report).
2 studies
GRADE not reported

Perioperative infraorbital nerve block vs Infiltration of the incision (peri-incisional infiltration)

Length of hospital stay · Children up to 13 years of age, undergoing cleft lip repair surgery

The review found no eligible studies for this question.

1 finding from 1 review

Infraorbital nerve block for postoperative pain following cleft lip repair in children 2016 · Cochrane All outcomes
The included studies did not report this outcome.
0 studies
No studies found