Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

462 questions · 474 findings · 56 reviews · Eyes and Vision

No studies found 147 · 31%GRADE not reported 15 · 3.2%Very low 89 · 18.8%Low 157 · 33.1%Moderate 52 · 11%High 14 · 3%

Regular‐dose postoperative 5‐Fluorouracil vs control

Intraocular pressure ( · participants with glaucoma surgery
3 findings from 1 review

Regular‐dose postoperative 5‐Fluorouracil vs control

Complications ‐ epithelial toxicity ‐ combined surgery · participants with glaucoma surgery

Regular‐dose postoperative 5‐Fluorouracil may leads to higher complications ‐ epithelial toxicity ‐ combined surgery compared with control (low certainty).

1 finding from 1 review

Intraoperative 5‐Fluorouracil vs placebo or control

Failure at 12 months Need for repeat surgery or uncontrolled IOP (usually more than 22 mm Hg) despite additional topical or systemic medications · participants with glaucoma surgery

Intraoperative 5‐Fluorouracil leads to lower failure at 12 months Need for repeat surgery or uncontrolled IOP… compared with placebo or control (high certainty).

1 finding from 1 review

Prism adaptation test with eye muscle surgery vs eye muscle surgery alone

Quality of life measures Measured at 3 years using the IXTQ scores for children, parents, or parent proxies (i.e. parents' perception of their children's quality of life). Scores could range from 0 (worst quality of life) to 100 (best quality of l... · people with intermittent exotropia, aged 5 to 49 years

The review found no eligible studies for this question.

1 finding from 1 review

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Proportion of participants who were medication‐free (not using eye drops) medium‐term · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery probably leads to higher proportion of participants who were medication‐free (not using… compared with phacoemulsification alone (moderate certainty).

1 finding from 1 review

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Mean change in unmedicated IOP24 months (medium‐term) · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery showed no clear difference in mean change in unmedicated IOP24 months (medium‐term) compared with phacoemulsification alone (high certainty).

1 finding from 1 review

Phacoemulsification + supraciliary microstent surgery vs phacoemulsification alone

Mean change in daily IOP‐lowering medicationsat 24 months (medium‐term) · people with open‐angle glaucoma

Phacoemulsification + supraciliary microstent surgery showed no clear difference in mean change in daily IOP‐lowering medicationsat 24 months… compared with phacoemulsification alone (moderate certainty).

1 finding from 1 review