Organ system failure ‐ Renal insufficiency leading to replacement therapy · children with haematological malignancy at risk of tumour lysis syndrome
It is very uncertain whether summary of findings: urate oxidase changes renal failure requiring renal replacement therapy ( compared with allopurinol (very low certainty).
1 finding from 1 review
Severe hypoglycaemia
It is very uncertain whether summary of findings: insulin detemir changes severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with insulin glargine (very low certainty).
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
It is very uncertain whether summary of findings: insulin detemir changes severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin glargine (very low certainty).
1 finding from 1 review
Severe hypoglycaemia
Summary of findings: insulin detemir probably leads to lower severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin detemir showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Mean GI symptom scores (during RT) · Men with prostate cancer
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse effects during treatment ‐ not reported · endometrial hyperplasia
The review found no eligible studies for this question.
1 finding from 1 review
Patients with severe exacerbations (requiring hospitalisation or ER visit) · children and adults with predominantly mild to moderate asthma
Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more exacerbations requiring… compared with placebo (moderate certainty).
1 finding from 1 review
Severe hypoglycaemia
Summary of findings: insulin glargine showed no clear difference in severe hypoglycaemia (n/N) Definition: symptomatic hypoglycaemia… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin glargine showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with NPH insulin (moderate certainty).
1 finding from 1 review
Severe hypoglycaemia
Summary of findings: insulin degludec showed no clear difference in severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with insulin detemir (low certainty).
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring 00:01‐05:59 (Davies 2014) or 23:00‐07:00 (BEGIN Young)
Summary of findings: insulin degludec showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin detemir (low certainty).
1 finding from 1 review
Severe hypoglycaemia
Summary of findings: insulin degludec showed no clear difference in severe hypoglycaemia (n/N) Definition: hypoglycaemia requiring third… compared with insulin glargine (low certainty).
1 finding from 1 review
Severe nocturnal hypoglycaemia (n/N) Definition: severe hypoglycaemia occurring from 22:00 to 06:59 h
Summary of findings: insulin degludec showed no clear difference in severe nocturnal hypoglycaemia (n/N) Definition: severe… compared with insulin glargine (low certainty).
1 finding from 1 review
Reoperation · patients with lumbar stenosis
SUMMARY OF FINDINGS FOR DECOMPRESSION leads to lower reoperations Number of patients requiring a revision surgery compared with INTERSPINOUS SPACERS (high certainty).
1 finding from 1 review
Reoperation · patients with lumbar stenosis
SUMMARY OF FINDINGS FOR DECOMPRESSION showed no clear difference in reoperations Number of patients requiring a revision surgery compared with FUSION (moderate certainty).
1 finding from 1 review
Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · children with stable wrist fracture, predominantly buckle (torus) fracturesa
1 finding from 1 review
Death during study period · acute presumed ischaemic stroke
Summary of findings table ‐ Anticoagulant showed no clear difference in death from all causes during treatment period compared with control (low certainty).
1 finding from 1 review
Deep vein thrombosis · acute presumed ischaemic stroke
It is very uncertain whether summary of findings table ‐ Anticoagulant changes deep vein thrombosis during treatment period compared with control (very low certainty).
1 finding from 1 review
Recurrent ischaemic or unknown stroke during treatment period · acute presumed ischaemic stroke
Summary of findings table ‐ Anticoagulant probably leads to lower recurrent ischaemic or unknown stroke during treatment period compared with control (moderate certainty).
1 finding from 1 review