Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

115 questions · 119 findings · 21 reviews · Headline outcomes only

No studies found 24 · 20.2%GRADE not reported 3 · 2.5%Very low 43 · 36.1%Low 30 · 25.2%Moderate 14 · 11.8%High 5 · 4.2%

Bakri balloon tamponade vs haemostatic square suturing to the lower segment of the uterus (intrauterine tamponade versus another mechanical/surgical method)

Blood transfusion (red cell or whole blood) · women with complete placenta praevia and intractable bleeding following caesarean section

It is very uncertain whether bakri balloon tamponade changes blood transfusion (red cell or whole blood) compared with haemostatic square suturing to the lower segment of the uterus… (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade (condom‐loaded catheter) vs uterovaginal packing (intrauterine tamponade versus another intrauterine tamponade method)

Blood transfusion (red cell or whole blood) · Women (aged between 20 and 40) diagnosed with primary PPH following 'normal' vaginal birth and unresponsive to medical treatment (Ashraf…

The review found no eligible studies for this question.

1 finding from 1 review

Modified B‐Lynch compression suture technique vs standard B‐Lynch compression suture (one uterine compression suture technique versus another uterine compression suture technique)

Blood transfusion (red cell or whole blood) · women with uncontrolled atonic PPH following caesarean section, and not responding to standard care (uterine massage, ecbolics and…

The review found no eligible studies for this question.

1 finding from 1 review

Long‐stored ('older') PRBC (≥ 21 days of storage) vs short‐stored (fresh) PRBC (< 21 days of storage)

Death from any cause · patients requiring blood transfusion (children with malaria and adults with a traumatic injury)

It is very uncertain whether long‐stored ('older') PRBC (≥ 21 days of storage) changes death from any cause compared with short‐stored (fresh) PRBC (< 21 days of storage) (very low certainty).

1 finding from 1 review

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care (moderate certainty).

1 finding from 1 review

DDAVP vs aprotinin

Number of participants receiving a red cell transfusion (total) · participants undergoing surgery

DDAVP may leads to higher number of participants receiving a red cell transfusion (total) compared with aprotinin (low certainty).

1 finding from 1 review

DDAVP vs placebo or usual care

Number of participants receiving a red cell transfusion (total) · participants with platelet dysfunction undergoing surgery

DDAVP showed no clear difference in number of participants receiving a red cell transfusion (total) compared with placebo or standard care: platelet dysfunction subgroup (low certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs longer storage duration

Mortality: in‐hospital mortality (within 7 days) · all conditions

It is very uncertain whether transfusion of RBCs of shorter changes mortality: in‐hospital mortality (within 7 days) compared with longer storage duration (very low certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: in‐hospital mortality (time points varied) · all conditions

Transfusion of RBCs of shorter showed no clear difference in mortality: in‐hospital mortality (time points varied) compared with standard practice storage duration (moderate certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: short‐term mortality (up to 30 days) ‐ neonates · all conditions

It is very uncertain whether transfusion of RBCs of shorter changes mortality: short‐term mortality (up to 30 days) ‐ neonates compared with standard practice storage duration (very low certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: short‐term mortality (up to 30 days) ‐ adults · all conditions

Transfusion of RBCs of shorter showed no clear difference in mortality: short‐term mortality (up to 30 days) ‐ adults compared with standard practice storage duration (moderate certainty).

1 finding from 1 review