Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,106 questions · 1,152 findings · 69 reviews

No studies found 216 · 18.8%GRADE not reported 448 · 38.9%Very low 122 · 10.6%Low 195 · 16.9%Moderate 127 · 11%High 44 · 3.8%

Low‐dose adjuvant radiotherapy vs standard‐dose adjuvant radiotherapy

Voice (Voice Handicap Index) · patients with HPV‐positive oropharyngeal carcinoma who have received minimally invasive transoral surgery

The review found no eligible studies for this question.

1 finding from 1 review

Hyperfractionated radiotherapy vs radiotherapy

Radiological response defined as the number of participants with a reduction in tumour size > 50% · children and young adults with diffuse brainstem glioma

It is very uncertain whether hyperfractionated radiotherapy changes radiological response defined as the number of participants with a… compared with conventional radiotherapy (very low certainty).

1 finding from 1 review

Hyperfractionated radiotherapy vs Conventional (standard) fractionation radiotherapy

Locoregional control · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Hyperfractionated radiotherapy led to lower locoregional control compared with conventional (standard) fractionation radiotherapy; GRADE not reported.

1 finding from 1 review

Hyperfractionated radiotherapy vs Conventional (standard) fractionation radiotherapy

Total mortality · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…

Hyperfractionated radiotherapy led to lower total mortality compared with conventional (standard) fractionation radiotherapy; GRADE not reported.

1 finding from 1 review

Hyperfractionated radiotherapy vs Conventional (standard) fractionation radiotherapy

Disease-free survival · People with primary squamous cell carcinoma of the oral cavity (ICD-O C01-C06) or oropharynx (ICD-O C09-C10); head and neck cancer trials…
1 finding from 1 review

Radiotherapy vs botulinum toxin

Reduction in the amount of saliva production in the short term using an objective measure · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

The review found no eligible studies for this question.

1 finding from 1 review