Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

459 questions · 589 findings · 78 reviews · All outcomes

No studies found 64 · 10.9%GRADE not reported 366 · 62.1%Very low 90 · 15.3%Low 49 · 8.3%Moderate 10 · 1.7%High 10 · 1.7%

Fluoride in dentifrice vs no treatment

Caries increment in permanent teeth · Children or adolescents

The NMR reported a difference between fluoride in dentifrice and no treatment at every displayed randomisation year; no GRADE assessment was reported.

1 finding from 1 review

Platelet-rich fibrin (PRF) graft vs Calcium hydroxide (CH)

Overall success (composite of clinical and radiographic success) · Mature permanent teeth with irreversible pulpitis and carious pulp exposure (treated with full pulpotomy)

Platelet-rich fibrin and calcium hydroxide showed no significant difference in success (ungraded; effect size not reported).

1 finding from 1 review

Platelet-rich fibrin (PRF) graft vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in immature permanent teeth undergoing pulpotomy

The two trials of PRF versus MTA for success gave contradictory results and were not pooled (ungraded).

1 finding from 1 review

Piezoelectric bone removal vs Conventional rotary handpiece

Trismus / maximum mouth opening (mean) · Adults with mandibular third molars requiring removal

Piezoelectric bone removal led to higher trismus / maximum mouth opening (mean) compared with conventional rotary handpiece; GRADE not reported.

1 finding from 1 review

WINSIX cylindrical implants vs WINSIX tapered implants

Implant failure · Adults with missing teeth who received osseointegrated root-formed oral implants, functionally loaded and followed for at least 1 year

WINSIX cylindrical implants showed no clear difference in implant failure compared with WINSIX tapered implants; GRADE not reported.

1 finding from 1 review

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Zinc oxide and eugenol (ZOE) pulpectomy

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate/MTA pulpotomy showed no clear difference in clinical failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.

1 finding from 1 review

Ferric sulphate (FS) + mineral trioxide aggregate (MTA) vs Zinc oxide and eugenol (ZOE) pulpectomy

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

Ferric sulphate/MTA pulpotomy showed no clear difference in radiological failure compared with zinc oxide and eugenol (ZOE) pulpectomy; GRADE not reported.

1 finding from 1 review

Phosphoric etching (acid) gel vs Mechanical debridement and polishing

Side effects (pain) · Adults with dental implants and healthy peri-implant soft tissues at baseline
1 finding from 1 review

Phosphoric etching (acid) gel vs Mechanical debridement and polishing

Change in probing pocket depth (PPD) · Adults with dental implants and healthy peri-implant soft tissues at baseline

Phosphoric etching (acid) gel showed no clear difference in change in probing pocket depth compared with mechanical debridement and polishing; GRADE not reported.

1 finding from 1 review

Phosphoric etching (acid) gel vs Mechanical debridement and polishing

Plaque · Adults with dental implants and healthy peri-implant soft tissues at baseline

Phosphoric etching (acid) gel showed no clear difference in plaque compared with mechanical debridement and polishing; GRADE not reported.

1 finding from 1 review

Calcium-enriched mixture (CEM) cement vs Mineral trioxide aggregate (MTA)

Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy

MTA and CEM performed comparably for clinical and radiographic success (2 RCTs, not pooled; ungraded).

1 finding from 1 review

Platelet-rich fibrin (PRF) graft vs No grafting

Radiographic healing - 1 year · People requiring retreatment of periapical lesions (failed root canal therapy)
1 finding from 1 review
  • Angerame 2015 (7 test, 4 control): no significant difference in healing of the lesion at 1 year; significant difference only at 2- and 3-month follow-up. Small preliminary study; no robust pooled analysis.
    1 study · 11 participants
    GRADE not reported

Electrical conductance or impedance vs Reference standard (histology, excavation, or enhanced visual examination)

Sensitivity for detection of enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Electrical conductance or impedance had a summary sensitivity of 0.83 (95% CrI 0.66, 0.92) for detecting enamel caries; low certainty.

1 finding from 1 review

Electrical conductance or impedance vs Reference standard (histology, excavation, or enhanced visual examination)

Specificity for detection of enamel caries · Asymptomatic children or adults suspected of enamel caries (clinical studies); extracted teeth (in vitro studies)

Electrical conductance or impedance had a summary specificity of 0.72 (95% CrI 0.44, 0.89) for detecting enamel caries; low certainty.

1 finding from 1 review