What do systematic reviews say?

Brain‐derived neurotrophic factor vs placebo

It is very uncertain whether brain‐derived neurotrophic factor changes improvement in disability grade Defined as achievement of a… compared with placebo (very low certainty).

• Pharmacological treatment other than corticosteroids, intravenous immunoglobulin and plasma exchange for… 2020 · Cochrane Headline outcomes only
  RR 1 [0.28, 3.54]
  1 study · 10 participants
  Very low

Methotrexate vs placebo

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  RR 1.21 [0.4, 3.7]
  1 study · 59 participants
  Moderate

Methotrexate vs placebo

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Low

Methotrexate vs placebo

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 59 participants
  Low

Methotrexate vs placebo

Methotrexate showed no clear difference in serious adverse events compared with placebo (moderate certainty).

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  RR 3.56 [0.39, 32.23]
  1 study · 59 participants
  Moderate

Interferon beta‐1a vs placebo

The review found no eligible studies for this question.

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Interferon beta‐1a vs placebo

Interferon beta‐1a showed no clear difference in participants who completed the study and did not restart IVIg… compared with placebo (moderate certainty).

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  RR 1 [0.54, 1.88]
  1 study · 49 participants
  Moderate

Interferon beta‐1a vs placebo

Interferon beta‐1a showed no clear difference in serious adverse events compared with placebo (low certainty).

• Immunomodulatory treatment other than corticosteroids, immunoglobulin and plasma exchange for chronic inflammatory… 2017 · Cochrane Headline outcomes only
  RR 4.5 [0.25, 80.05]
  1 study · 67 participants
  Low

PE vs intravenous immunoglobulin (IVIG)

• Plasma exchange for generalised myasthenia gravis 2002 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 87 participants
  High