Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

121 questions · 122 findings · 19 reviews · Headline outcomes only

No studies found 25 · 20.5%GRADE not reported 23 · 18.9%Very low 20 · 16.4%Low 36 · 29.5%Moderate 15 · 12.3%High 3 · 2.5%

Sunlight (with or without filters or amplification) vs other sources of phototherapy

Treatment failure requiring exchange transfusionc,d · infants with confirmed hyperbilirubinemia

Sunlight (with or without filters or amplification) showed no clear difference in treatment failure requiring exchange transfusionc,d compared with other sources of phototherapy (low certainty).

1 finding from 1 review

Sunlight (with or without filters or amplification) vs other sources of phototherapy

Acute bilirubin encephalopathy · infants with confirmed hyperbilirubinemia

Sunlight (with or without filters or amplification) may leads to lower acute bilirubin encephalopathyc,f compared with other sources of phototherapy (low certainty).

1 finding from 1 review

Sunlight (with or without filters or amplification) vs other sources of phototherapy

Proportion of days of effective treatmenti · infants with confirmed hyperbilirubinemia

It is very uncertain whether sunlight (with or without filters or amplification) changes proportion of days of effective treatmenti compared with other sources of phototherapy (very low certainty).

1 finding from 1 review

Intravenous fluid supplementation vs no fluid supplementation

Proportion of infants who required exchange transfusion · newborn infants with unconjugated hyperbilirubinaemia undergoing phototherapy

Intravenous fluid supplementation may leads to lower proportion of infants who required exchange transfusion compared with no fluid supplementation (low certainty).

1 finding from 1 review

NB‐UVB vs PUVA

Patient‐reported changes in symptoms ‐ not measured · atopic eczema

The review found no eligible studies for this question.

1 finding from 1 review

NB‐UVB vs PUVA

Investigator Global Assessment · atopic eczema

It is very uncertain whether summary of findings table ‐ NB‐UVB changes investigator Global Assessment compared with PUVA (very low certainty).

1 finding from 1 review