Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

75 questions · 75 findings · 23 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 10 · 13.3%GRADE not reported 0 · 0%Very low 16 · 21.3%Low 27 · 36%Moderate 17 · 22.7%High 5 · 6.7%

beta‐lactam monotherapy vs beta‐lactam (cloxacillin) plus aminoglycoside (gentamicin)

Treatment failure ‐ different beta‐lactam · people with cancer who have febrile neutropenia

beta‐lactam monotherapy may leads to lower treatment failure ‐ different beta‐lactam compared with beta‐lactam‐aminoglycoside combination therapy (low certainty).

1 finding from 1 review

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

All cause‐mortality · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to higher all cause‐mortality compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Febrile patients and episodes · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to lower febrile patients and episodes compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Intervention not reported

Antibiotics prior to long‐term CVC insertion versus control: catheter‐related infections · adults and children diagnosed with an oncologic disease with a newly‐inserted long‐term CVC who were at risk of neutropenia due to…

The intervention showed no clear difference in antibiotics prior to long‐term CVC insertion versus control:… (moderate certainty).

1 finding from 1 review

Intervention not reported

Antibiotic versus heparin only lock/flush solution: catheter‐related infections · adults and children diagnosed with an oncologic disease with a newly‐inserted long‐term CVC who were at risk of neutropenia due to…

The intervention probably leads to lower antibiotic versus heparin only lock/flush solution: catheter‐related… (moderate certainty).

1 finding from 1 review