Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,340 questions · 1,512 findings · 205 reviews

No studies found 317 · 21%GRADE not reported 358 · 23.7%Very low 356 · 23.5%Low 271 · 17.9%Moderate 173 · 11.4%High 37 · 2.4%

Open surgical exposure vs Closed surgical exposure

Gum health: midpalatal gingival recession · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in gum health: midpalatal gingival recession compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Patient response: satisfaction with treatment (satisfactory vs unsatisfactory) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in patient response: satisfaction with treatment (satisfactory vs… compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Aesthetics: canine rated as abnormal tooth colour · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in aesthetics: canine rated as abnormal tooth colour compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Success of surgery (eruption of the canine crown sufficient for orthodontic alignment, without repeated surgery) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in success of surgery (eruption of the canine crown sufficient for… compared with closed surgical exposure (low certainty).

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Treatment time: length of time in the operating theatre (first incision to final suture) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

It is very uncertain whether open surgical exposure changes treatment time: length of time in the operating theatre (first… compared with closed surgical exposure (very low certainty).

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Gum health: radiographic crestal bone level · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in gum health: radiographic crestal bone level compared with closed surgical exposure; GRADE not reported.

1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Aesthetics of the treated canine compared with the untreated contralateral canine · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)
1 finding from 1 review

Open surgical exposure vs Closed surgical exposure

Clinical attachment level (CAL) · People with maxillary palatally displaced (impacted) canines, unilateral or bilateral (children/adolescents; mean ages 14.2 to 17.5 years)

Open surgical exposure showed no clear difference in gum health: clinical attachment level (CAL) compared with closed surgical exposure (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs placebo

Quality of life/satisfaction with care for either recipients of care or carers: significant change in quality of life/satisfaction · patients with schizophrenia

The review found no eligible studies for this question.

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Sedation/tranquillisation: Not sedated ‐ at four hours · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in sedation/tranquillisation: Not sedated ‐ at four hours compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 1. Requiring supplementary medication ‐ antipsychotics · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in global state: 1. Requiring supplementary medication ‐ antipsychotics compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Global state: 2. Requiring 3 or more injections ‐ over 7 days · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE may leads to lower global state: 2. Requiring 3 or more injections ‐ over 7 days compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Clinical response: no clinically significant response in mental state · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in mental state: 1. No important improvement compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review

ZUCLOPENTHIXOL ACETATE vs STANDARD DRUG CARE

Adverse effects: Specific ‐ dystonia during 24 hours · patients with acute schizophrenia and similar serious mental illnesses

ZUCLOPENTHIXOL ACETATE showed no clear difference in adverse effects: Movement disorders ‐ dystonia (spasmodic postural… compared with STANDARD DRUG CARE (low certainty).

1 finding from 1 review