Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

111 questions · 123 findings · 10 reviews · Gynaecology and Fertility

No studies found 21 · 17.1%GRADE not reported 1 · 0.8%Very low 34 · 27.6%Low 49 · 39.8%Moderate 18 · 14.6%High 0 · 0%

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Multiple pregnancy rate · intrauterine insemination (IUI) in women with infertility

Gonadotrophins with anti‐oestrogens showed no clear difference in multiple pregnancy rate per couple compared with gonadotropins alone (low certainty).

1 finding from 1 review

Gonadotrophins with anti‐oestrogens vs gonadotropins alone

Clinical pregnancy rate · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotrophins with anti‐oestrogens changes clinical pregnancy rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Oestrogen therapy alone vs placebo

Venous thrombo‐embolism (DVT or PE): CEE 0.625 mg (moderate dose) · relatively healthy postmenopausal women

Oestrogen‐only hormone therapy (HT) showed no clear difference in venous thromboembolism (DVT or PE): CEE 0.625 mg (moderate dose) compared with placebo (moderate certainty).

1 finding from 1 review

Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins

Live birth rate per couple · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether aromatase inhibitors with gonadotropins changes live birth rate per couple compared with anti‐oestrogens with gonadotropins (very low certainty).

1 finding from 1 review

Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins

Multiple pregnancy rate · intrauterine insemination (IUI) in women with infertility

Aromatase inhibitors with gonadotropins showed no clear difference in multiple pregnancy rate per couple compared with anti‐oestrogens with gonadotropins (low certainty).

1 finding from 1 review

Aromatase inhibitors with gonadotropins vs anti‐oestrogens with gonadotropins

Clinical pregnancy rate · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether aromatase inhibitors with gonadotropins changes clinical pregnancy rate per couple compared with anti‐oestrogens with gonadotropins (very low certainty).

1 finding from 1 review