Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

230 questions · 243 findings · 23 reviews · Headline outcomes only

No studies found 52 · 21.4%GRADE not reported 10 · 4.1%Very low 85 · 35%Low 51 · 21%Moderate 37 · 15.2%High 8 · 3.3%

PCC vs usual care

All thrombotic events (including myocardial infarction, ischaemic stroke, other arterial thromboembolism, and venous thromboembolism) · cardiac surgery for the treatment of non‐surgical bleeding

PCC showed no clear difference in thrombotic events compared with standard treatment (moderate certainty).

1 finding from 1 review