It is very uncertain whether skin grafts and tissue replacements changes total incidence of lower limb amputations compared with placebo or standard care (very low certainty).
Fast‐acting nicotine replacement therapy showed no clear difference in smoking cessation compared with nicotine patch (high certainty).
It is very uncertain whether fast‐acting nicotine replacement therapy changes treatment withdrawals compared with nicotine patch (very low certainty).
Effects of clinically‐indicated replacement showed no clear difference in catheter‐related blood stream infection (during hospitalisation) compared with routine change of peripheral intravenous catheters (low certainty).
Effects of clinically‐indicated replacement showed no clear difference in thrombophlebitis (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).
Effects of clinically‐indicated replacement showed no clear difference in thrombophlebitis (per device days) (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).
Effects of clinically‐indicated replacement showed no clear difference in all‐cause blood stream infection (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).
Effects of clinically‐indicated replacement probably leads to higher infiltration (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).
Effects of clinically‐indicated replacement probably leads to higher catheter blockage (during hospitalisation) compared with routine change of peripheral intravenous catheters (moderate certainty).
Preloading nicotine replacement therapy (NRT) probably leads to higher smoking cessation compared with standard‐use NRT (moderate certainty).
Preloading nicotine replacement therapy (NRT) showed no clear difference in overall serious adverse events compared with standard‐use NRT (low certainty).
It is very uncertain whether preloading nicotine replacement therapy (NRT) changes treatment withdrawals compared with standard‐use NRT (very low certainty).
Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).
Nicotine replacement therapy showed no clear difference in mean birthweight (g) compared with control (low certainty).
Nicotine replacement therapy showed no clear difference in miscarriage and spontaneous abortion compared with control (low certainty).
The intervention led to lower composite: Preference for replacement over repair - Scenario 8:…; GRADE not reported.
The intervention showed no clear difference in composite: Preference for replacement over repair - Scenario 2: loss…; GRADE not reported.