Live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32 kg/m2 · women with polycystic ovary syndrome
It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI < 30 kg/m2 or ≤ 32… compared with clomiphene citrate (very low certainty).
Live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
It is very uncertain whether metformin changes live birth rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (very low certainty).
Gastrointestinal adverse events · women with polycystic ovary syndrome
The review found no eligible studies for this question.
no estimate extracted
Studies not reported
No studies found
no estimate extracted
Studies not reported
No studies found
Clinical pregnancy rate per woman Participants with BMI < 30 kg/m2 or ≤ 32 kg/m2a · women with polycystic ovary syndrome
Metformin may leads to higher clinical pregnancy rate per womanaParticipants with BMI < 30 kg/m2… compared with clomiphene citrate (low certainty).
Clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin may leads to lower clinical pregnancy rate per woman aParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Ovulation rate per woman fParticipants with BMI < 30 kg/m2 · women with polycystic ovary syndrome
Metformin showed no clear difference in ovulation rate per woman fParticipants with BMI < 30 kg/m2 compared with clomiphene citrate (low certainty).
Ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 · women with polycystic ovary syndrome
Metformin may leads to lower ovulation rate per woman fParticipants with BMI ≥ 30 kg/m2 compared with clomiphene citrate (low certainty).
Hirsutism ‐ Clinical F‐G score · adult women with PCOS
1 finding from 1 review
Hirsutism ‐ Clinical F‐G score · adolescent women with PCOS
1 finding from 1 review
Adverse events ‐ Severe · adult women with PCOS
Metformin may leads to higher adverse events ‐ Severe compared with oral contraceptive pill (OCP) (low certainty).
1 finding from 1 review
Adverse event ‐ Severe · adolescent women with PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Minor adverse events · adolescent women with PCOS
It is very uncertain whether metformin changes adverse event ‐ Minor compared with oral contraceptive pill (OCP) (very low certainty).
1 finding from 1 review
Improved menstrual pattern · adolescent women with PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Acne ‐ Visual analogue scale or Clinical acne score · adolescent women with PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Body‐mass index (BMI) · adolescent women with PCOS
1 finding from 1 review
Minor adverse events · adult women with PCOS
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Improved menstrual pattern · adult women with PCOS
1 finding from 1 review
Acne ‐ Visual analogue scale or Clinical acne score · adult women with PCOS
1 finding from 1 review
Body‐mass index (BMI) · adult women with PCOS
1 finding from 1 review
Live birth rate per woman ‐ long protocol GnRH‐agonist · women with polycystic ovary syndrome
Metformin showed no clear difference in live birth rate per woman ‐ long protocol GnRH‐agonist compared with placebo or no treatment (low certainty).
1 finding from 1 review