Metformin vs oral contraceptive pill (OCP): Minor adverse events
- Population
- adolescent women with PCOS
- Intervention
- Metformin
- Comparison
- oral contraceptive pill (OCP)
- Outcome
- Minor adverse events
It is very uncertain whether metformin changes adverse event ‐ Minor compared with oral contraceptive pill (OCP) (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Metformin vs oral contraceptive pill (OCP) Adverse event ‐ Minor · adolescent women with PCOS It is very uncertain whether metformin changes adverse event ‐ Minor compared with oral contraceptive pill (OCP) (very low certainty). Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in… (2020) · Cochrane Headline outcomes only | OR 11.67 [0.53, 258.56] | 1 study · 22 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Metformin versus the combined oral contraceptive pill for hirsutism, acne, and menstrual pattern in polycystic ovary syndrome 2020 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Metformin vs metformin combined with OCP · adolescent women with PCOS · 1 review
- Metformin vs metformin combined with OCP · adult women with PCOS · 1 review
- Metformin vs oral contraceptive pill (OCP) · adult women with PCOS · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.