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Evidence found and GRADE certainty

88 questions · 89 findings · 14 reviews · Skin

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No studies found 40 · 44.9%GRADE not reported 4 · 4.5%Very low 17 · 19.1%Low 20 · 22.5%Moderate 7 · 7.9%High 1 · 1.1%

Etanercept vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Ustekinumab vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Guselkumab vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Secukinumab vs placebo

Proportion of participants without relapse in the long term ‐ not reported · chronic palmoplantar pustulosis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Long‐term sequelae · patients with HIV‐1 infection and a pre‐established clinical need for treatment with an antiretroviral drug regimen containing abacavir…

The review found no eligible studies for this question.

1 finding from 1 review

Oral propranolol vs topical timolol

Adverse events experienced at short or long term ‐ general adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

It is very uncertain whether oral propranolol changes adverse events experienced at short or long term ‐ general adverse… compared with topical timolol (very low certainty).

1 finding from 1 review

Oral propranolol vs placebo

Adverse events experienced at short or long term ‐ Serious adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in adverse events experienced at short or long term ‐ Serious adverse… compared with placebo (low certainty).

1 finding from 1 review

Imiquimod vs vehicle

Long‐term clinical cure (beyond 6 months after start of treatment) (completely cleared long term) · molluscum contagiosum

Imiquimod showed no clear difference in long‐term clinical cure (beyond 6 months after start of treatment)… compared with vehicle (moderate certainty).

1 finding from 1 review