Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

118 questions · 119 findings · 8 reviews · HIV/AIDS

No studies found 0 · 0%GRADE not reported 5 · 4.2%Very low 20 · 16.8%Low 41 · 34.5%Moderate 49 · 41.2%High 4 · 3.4%

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infant Mortality at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in infant Mortality at 24 months among those uninfected at birth compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

HIV Transmission or Death at 24 months among those uninfected at birth · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… showed no clear difference in HIV Transmission or Death at 24 months among those uninfected at birth compared with an extended NVP regimen administered to infants (moderate certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infants with Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

An extended NVP plus ZDV dual regimen administered to infants for 14… may leads to higher infants with any Severe Adverse Events compared with an extended NVP regimen administered to infants (low certainty).

1 finding from 1 review

An extended NVP plus ZDV dual regimen administered to infants for 14 weeks vs an extended NVP regimen administered to infants

Infants with Probably Related Severe Adverse Events · Breastfeeding infants of HIV‐infected mothers

It is very uncertain whether an extended NVP plus ZDV dual regimen administered to infants for 14… changes infants with Probably Related Severe Adverse Events compared with an extended NVP regimen administered to infants (very low certainty).

1 finding from 1 review

Social cognitive theory for promotion of condom use vs no intervention

Consistent application of condom by FSWs · sex workers

Social cognitive theory for promotion of condom use showed no clear difference in consistent application of condom by FSWs compared with no intervention (moderate certainty).

2 findings from 1 review

Social cognitive theory for promotion of condom use vs no intervention

HIV knowledge among FSWs at 6‐month · sex workers

It is very uncertain whether social cognitive theory for promotion of condom use changes HIV knowledge among FSWs at 6‐month compared with no intervention (very low certainty).

1 finding from 1 review

Social cognitive theory for promotion of condom use vs no intervention

Psychosocial barriers to condom use among FSWs at 6‐month · sex workers

Social cognitive theory for promotion of condom use showed no clear difference in psychosocial barriers to condom use among FSWs at 6‐month compared with no intervention (moderate certainty).

1 finding from 1 review

Social cognitive theory for promotion of condom use vs no intervention

Psychosocial barriers to condom use self‐efficacy among FSWs at 6‐month · sex workers

It is very uncertain whether social cognitive theory for promotion of condom use changes psychosocial barriers to condom use self‐efficacy among FSWs at… compared with no intervention (very low certainty).

1 finding from 1 review

Social cognitive theory for promotion of condom use vs no intervention

Consistent condom use by FSWs with clients at 6‐month · sex workers

Social cognitive theory for promotion of condom use showed no clear difference in consistent condom use by FSWs with clients at 6‐month compared with no intervention (moderate certainty).

1 finding from 1 review

Intervention not reported

HIV Transmission at 7 months among those whose HIV diagnostic testing was negative at one month after birth · breastfeeding infants of HIV‐infected mothers

It is very uncertain whether the intervention changes HIV Transmission at 7 months among those whose HIV diagnostic… (very low certainty).

1 finding from 1 review

Intervention not reported

Infant Mortality at 18 months · breastfeeding infants of HIV‐infected mothers

It is very uncertain whether the intervention changes infant Mortality at 18 months (very low certainty).

1 finding from 1 review

Intervention not reported

HIV Transmission or Death at 18 months among those whose HIV diagnostic testing was negative at one month after birth · breastfeeding infants of HIV‐infected mothers

It is very uncertain whether the intervention changes HIV Transmission or Death at 18 months among those whose HIV… (very low certainty).

1 finding from 1 review

Intervention not reported

Infants with Grade 3/4 Signs or Symptoms · breastfeeding infants of HIV‐infected mothers

It is very uncertain whether the intervention changes infants with Grade 3/4 Signs or Symptoms (very low certainty).

1 finding from 1 review

Intervention not reported

Infants with Grade 3/4 Laboratory Abnormalities · breastfeeding infants of HIV‐infected mothers

It is very uncertain whether the intervention changes infants with Grade 3/4 Laboratory Abnormalities (very low certainty).

1 finding from 1 review

Intervention not reported

Infant with Toxicity Events leading to cessation of ZDV · breastfeeding infants of HIV‐infected mothers

It is very uncertain whether the intervention changes infant with Toxicity Events leading to cessation of ZDV (very low certainty).

1 finding from 1 review

An extended ZDV/3TC/LPV/r regimen administered to mothers vs an extended ZDV/3TC/ABC administered to mothers

HIV transmission at 6 months among those whose HIV diagnostic testing was negative within 96 hours of birth · HIV‐infected mothers and their breastfeeding infants

An extended ZDV/3TC/LPV/r regimen administered to mothers showed no clear difference in HIV transmission at 6 months among those whose HIV diagnostic… compared with an extended ZDV/3TC/ABC administered to mothers (low certainty).

1 finding from 1 review